Postdoctoral Scientist - Systems Oncology Group

Reference Number: MI/17/25_2
Starting Salary: in the range of £30,000 - £39,800 (depending on qualifications and experience)
Closing Date: 02 November 2017
Duration of Post: Fixed term for 3 years

About the role:
Dr Claus Jorgensen, Group Leader of the Systems Oncology Group, is looking for a Postdoctoral scientist to join his group. This is a great opportunity for a self-motivated, innovative and organised candidate with excellent communication skills to work in a dynamic laboratory undertaking cutting edge research.

The goal of the Systems Oncology Group is to understand how aberrations in cellular signalling affect tumour progression and response to therapy. In particular, we are interested in understanding how signalling between cancer cells and cells in the tumour microenvironment promote tumour progression and drug resistance. Using global approaches such as proteomics, mass cytometry, CRISPR and RNA sequencing we aim to identify and understand the mechanisms of cell-cell communication (Tape et al Cell 2016, Jorgensen et al Science 2009, Tape et al Mol Cell Proteomics 2014, Tape et al Anal Chem 2014, Worboys et al Nature Methods 2014). You will join a multidisciplinary team to study these problems.

About you:
You will develop an independent research project to address how cells in the tumour stroma influence tumour cell therapeutic response. Key to the success of the project will be integration of high dimensional quantitative signalling data (proteomics data and single cell CyTOF data) with phenotypic data (e.g apoptosis, proliferation etc). You will be competent in computational data analysis (for example using machine learning, Bayesian or PLSR). Experience in computational analysis of high dimensional data either from FACS, CyTOF, imaging or proteomics and have demonstrated ability to develop data-driven models is beneficial. Wet-lab experience is not a requirement, but an advantage. You will be expected to interact with members in the laboratory and contribute to the design and development of on-going proteomics research projects in support of the Systems Oncology group.

You should have a PhD in computational biology, systems biology, cell biology, biochemistry or a relevant field. Experience in computational data analysis of cellular signalling (information processing) is essential. 

Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research.  The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.
 
We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK Manchester Institute, Paterson Building) in South Manchester (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe.  These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients.  Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials.

The Institute has access to outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry. 

How to apply?
To apply for this position please complete an equal opportunities form and submit along with a CV and accompanying CV cover sheet to jobs@cruk.manchester.ac.uk. Please ensure you detail the names of three referees and quote the job reference number above. A cover letter is optional.

Informal enquiries can be directed to Dr Claus Jorgensen via email: claus.jorgensen@ cruk.manchester.ac.uk.

Additional Information:
On the 26th April 2017 The Paterson Building, which housed most of the Cancer Research UK (CRUK) Manchester Institute, caught fire resulting in significant damage. We are striving to rebuild our world-class research facilities and we would like to make you aware that in the meantime, the primary place of work for this position will be at the internationally-renowned life sciences campus at Alderley Park, which has excellent facilities to carry out research. We anticipate that this will be for a few years, after which we will return to our original site in Withington, Manchester, next to The Christie NHS Foundation Trust (Wilmslow Road, M20 4BX).

 

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Created Date: 28 September 2017