Publications

Wiseman DH, Small HF, Wilks DP, Waddell ID, Dennis MW, Ogilvie DJ, Somervaille TC. Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment. Br J Haematol. 2014 Jul;166(1):145-8.

Jude JG, Spencer GJ, Huang X, Somerville TD, Jones DR, Divecha N, Somervaille TC. A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival. Oncogene. 2014 Mar 31. doi: 10.1038/onc.2014.77. [Epub ahead of print]

Wiseman DH, Small HF, Wilks DP, Waddell ID, Dennis MW, Ogilvie DJ, Somervaille TC. (2014) Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment. Br J Haematol. 166(1):145-8.

Huang X, Spencer GJ, Lynch JT, Ciceri F, Somerville TD, Somervaille TC. (2014) Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells. Leukemia. 28(5):1081-91.

Greystoke BF, Huang X, Wilks DP, Atkinson S, Somervaille TC. (2013) Very high frequencies of leukaemia-initiating cells in precursor T-acute lymphoblastic leukaemia may be obscured by cryopreservation. Br J Haematol. 163(4):538-41.

Lynch JT, Cockerill MJ, Hitchin JR, Wiseman DH, Somervaille TC. CD86 expression as a surrogate cellular biomarker for pharmacologic inhibition of the histone demethylase LSD1. (2013) Anal Biochem. 442(1):104-6.

Wiseman DH, Greystoke BF, Somervaille TC. The variety of leukemic stem cells in myeloid malignancy. (2013) Oncogene. 33(24):3091-8.

Lynch JT, Somerville TD, Spencer GJ, Huang X, Somervaille TC. TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell Death Dis. 2013 4:e573.

White DJ, Unwin RD, Bindels E, Pierce A, Teng HY, Muter J, Greystoke B, Somerville TD, Griffiths J, Lovell S, Somervaille TC, Delwel R, Whetton AD, Meyer S. Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability. PLoS One. 2013 8(6):e66510.

Lynch JT, Somerville TD, Spencer GJ, Huang X, Somervaille TC. TTC5 is required to prevent apoptosis of acute myeloid leukemia stem cells. Cell Death Dis. 2013 4:e573.

Lynch JT, Harris WJ, Somervaille TC. (2012) LSD1 inhibition: a therapeutic strategy in cancer? Expert Opin Ther Targets. 2012

Harris WJ, Huang X, Lynch JT, Spencer GJ, Hitchin JR, Li Y, Ciceri F, Blaser JG, Greystoke BF, Jordan AM, Miller CJ, Ogilvie DJ, Somervaille TC. (2012) The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell. 21(4):473-487.

Arnold CP, Tan R, Zhou B, Yue SB, Schaffert S, Biggs JR, Doyonnas R, Lo MC, Perry JM, Renault VM, Sacco A, Somervaille T, Viatour P, Brunet A, Cleary ML, Li L, Sage J, Zhang DE, Blau HM, Chen C, Chen CZ. (2011) MicroRNA programs in normal and aberrant stem and progenitor cells. Genome Res. 21(5):798-810.

Somervaille TC, Cleary ML. (2010) Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells? Int J Hematol. 91(5):735-741.

Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML. (2010) The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res. 70(9):3833-3842.

Liedtke M, Ayton PM, Somervaille TC, Smith KS, Cleary ML. (2010) Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6. Blood. 116(1):63-70

T C P Somervaille, C J Matheney, G J Spencer, J L Rinn, D M Witten, H Y Chang, S A Shurtleff, J R Downing and M L Cleary (2009). Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 4(2):129-140.

Z Wang, K S Smith, M Murphy, O Piloto, T C P Somervaille and M L Cleary (2008). Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. Nature 455(7217):1205-1209.

Viatour, T C P Somervaille, S Venkatasubrahmanyam, S C Kogan, M E McLaughlin, I L Weissman, A J Butt, E Passegué and J Sage (2008). Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell 3(4):416-428.

P Wong, M Iwasaki, T C P Somervaille, C W E So and M L Cleary (2007). Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes and Development 21(21):2762-2774.

Somervaille TC, Cleary ML. (2006) PU.1 and Junb: suppressing the formation of acute myeloid leukemia stem cells. Cancer Cell. 10(6):456-457.

T C P Somervaille and M L Cleary (2006). Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 10(4): 257-268.

A Yokoyama, T C P Somervaille, K S Smith, O Rosenblatt-Rosen, M Meyerson and M L Cleary (2005). The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Cell 123(2): 207-218.

T C P Somervaille, I M Hann, G Harrison, T O Eden, B E Gibson, F G Hill, C Mitchell, S E Kinsey, A J Vora, J S Lilleyman on behalf of the MRC Childhood Leukaemia Working Party (2003). Intraocular relapse of childhood acute lymphoblastic leukaemia. British Journal of Haematology 121(2): 280-288.

T C P Somervaille, D C Linch and A Khwaja (2003). Different levels of p38 MAP kinase activity mediate distinct biological effects in primary human erythroid progenitors. British Journal of Haematology 120(5): 876-886.

M J Watts, T C P Somervaille, S J Ings, F Ahmed, A Khwaja, K Yong and D C Linch (2002). Variable product purity and functional capacity after CD34 selection: a direct comparison of the CliniMACS® (v2.1) and Isolex® 300i (v2.5) clinical scale devices. British Journal of Haematology 118(1): 117-123.

T C P Somervaille, D C Linch and A Khwaja (2001). Growth factor withdrawal induces apoptosis in primary human erythroid progenitors through a pathway involving glycogen synthase kinase-3 and Bax. Blood 98(5): 1374-1381.

T C P Somervaille, S Kirk, A Dogan, G V Landon and S Mackinnon (1999). Fulminant hepatic failure caused by adenovirus infection following bone marrow transplantation for Hodgkin's Disease. Bone Marrow Transplantation 24(1): 99-101.