Publications

Tape C, Ling S, Dimitriadi M, McMahon K, Worboys J, Leong HS, Norie I, Miller C, Poulogiannis G, Lauffenburger DL, Jørgensen C. Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. Cell (2016) 165(4). AOP Open Access 

Locard-Paulet M, Lim L, Veluscek G, McMahon K, Sinclair J, van Weverwijk A, Worboys JD, Yuan Y, Isacke CM, Jørgensen C. Phosphoproteomic analysis of interacting tumor and endothelial cells identifies regulatory mechanisms of transendothelial migration. Sci Signal. 2016; 9(414):ra15.

So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015; 8(371):rs3.

Tape CJ, Worboys JD, Sinclair J, Gourlay R, Vogt J, Broster KM, Trost M, Lauffenburger DA, Lamont DJ, Jørgensen C. Reproducible Automated Phosphopeptide Enrichment using Magnetic TiO2 and Ti-IMAC.Anal Chem. 2014 86(20):10296-302.

Worboys JD, Sinclair J, Yuan Y, Jørgensen C. Systematic evaluation of quantotypic peptides for targeted analysis of the human kinome. Nat Methods. 2014 11(10):1041-4.

Tape CJ, Norrie IC, Worboys JD, Lim L, Lauffenburger DA, Jørgensen C. Cell-specific labeling enzymes for analysis of cell-cell communication in continuous co-culture. Mol Cell Proteomics. 2014 13(7):1866-76.

Djidja MC, Chang J, Hadjiprocopis A, Schmich F, Sinclair J, Mršnik M, Schoof EM, Barker HE, Linding R, Jørgensen C, Erler JT. Identification of Hypoxia-Regulated Proteins Using MALDI-Mass Spectrometry Imaging Combined with Quantitative Proteomics. J Proteome Res. 2014 Apr 24. [Epub ahead of print]

Anton KA, Sinclair J, Ohoka A, Kajita M, Ishikawa S, Benz PM, Renne T, Balda M, Jorgensen C, Matter K, Fujita Y. PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium. J Cell Sci. 2014 Jun 24. pii: jcs.149674. [Epub ahead of print]

Girotti MR*., Pedersen M., Sanchez-Laorden B., Viros A., Turajlic S., Niculescu- Duvaz D., Zambon A., Sinclair J., Hayes A., Gore M., Lorigan P., Springer C., Larkin J., Jørgensen C., Marais R. Inhibiting EGF receptor or SRC family kinase signalling overcomes BRAF inhibitor resistance in Melanoma. Cancer Discovery 2013 (2):158-67

Jorgensen C, Poliakov A.Proteomics analysis of contact-initiated eph receptor-ephrin signaling. Methods Mol Biol. 2013;1066:1-16

Jørgensen C, Locard-Paulet M. Analysing signalling networks by mass spectrometry. Amino Acids. 2012 43(3):1061-74

Janes PW*, Griesshaber B., Atapattu L., Nievergall E., Hii LL., Mensinga A., Chheang C., Day BW., Boyd AW., Bastiaens PI., Jørgensen C., Pawson T., Lackmann M. Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors. J Cell Biol 2011 195(6) 1033-45

Hakim-Weber R*, Krogsdam AM, Jørgensen C, Fischer M, Prokesch A, Bogner-Strauss JG, Bornstein SR, Hansen JB, Madsen L, Kristiansen K, Trajanoski Z, Hackl H. Transcriptional regulatory program in wild-type and retinoblastoma gene-deficient mouse embryonic fibroblasts during adipocyte differentiation. BMC Res Notes. 2011 (4):157

Hallenborg P*, Jørgensen C*, Petersen RK, Feddersen S, Araujo P, Markt P, Langer T, Furstenberger G, Krieg P, Koppen A, Kalkhoven E, Madsen L, Kristiansen K. Epidermis-type lipoxygenase 3 regulates adipocyte differentiation and peroxisome proliferator-activated receptor gamma activity. Mol Cell Biol. 2010 (16):4077-91

Hao Q*, Hansen JB, Petersen RK, Hallenborg P, Jørgensen C, Cinti S, Larsen PJ, Steffensen KR, Wang H, Collins S, Wang J, Gustafsson JA, Madsen L, Kristiansen K. ADD1/SREBP1c activates the PGC1-alpha promoter in brown adipocytes. Biochim Biophys Acta. 2010 1801(4):421-9

Jørgensen C*, Sherman A, Chen GI, Pasculescu A, Poliakov A, Hsiung M, Larsen B, Wilkinson DG, Linding R, Pawson T. Cell-specific information processing in segregating populations of Eph receptor-ephrin-expressing cells. Science 2009 326 (5959):1502-9

Tan CSH*, Bodenmiller B*, Pasculescu A, Jovanovic M, Hengartner M, Jørgensen C, Bader G, Aebersold R, Pawon T, Linding R. Comparative analysis of protein phosphorylation reveals Evolutionary conserved disease networks. Sci. Signal. 2009 2(81):ra39

Chang Q*, Jørgensen C, Pawson T, Hedley D. Effects of Dasatinib on EphA2 Receptor Tyrosine Kinase Activity and Downstream Signaling in Pancreatic Cancer. British Journal of Cancer, 2008 99(7):1074-82

Miller ML*, Jensen LJ*, Diella F, Jørgensen C, Li L, Sicheritz-Ponten T, Knapp S, Blom N, Li S, Bork P, Cesareni G, Pawson T, Turk BE, Yaffe MB, Brunak S, Linding R. Linear motif atlas for phosphorylation-dependent signaling, Science Signaling 2008 1(35):ra2

Chen GI*, Tisayakorn S, Jørgensen C, D’Ambrosio L, Goudreault M, Gingras AC. PPR4/KIAA1622 defines a novel stable cytosolic complex for phosphoprotein phosphatase 4. J Biol. Chem., 2008 283(43):29273-84

Zogopoulos G*, Jørgensen C, Bacani J, Montpetit A, Lepage P, Ferretti V, Chad L, Selvarajah S, Zanke B, Hudson T, Pawson T, Gallinger S. Germline EPHB2 receptor variants in familial colorectal cancer, PLoS ONE 2008 3(8)e2885

Linding R*, Jensen LJ*, Ostheimer GJ*, van Vugt M, Jørgensen C, Miron IM, Diella F, Colwill K, Taylor L, Elder K, Metalnikov P, Nguen V, Pasculescu A, Jin J, Park JG, Samson LD, Woodgett JR, Russel RB, Bork P, Yaffe MB, Pawson T. Systematic discovery of in vivo phosphorylation networks. Cell 2007 129:1415-1426

Jones N*, Hardy WR, Friese MB, Jørgensen C, Smith MJ, Woody NM, Burden S, Pawson T. Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. Mol Cell Biol 2007 27(13):4759-73

Hansen JB*, Jørgensen C, Petersen RK, Hallenborg P, De Matteis R, Boye HA, Petrovic N, Enerbäck SE, Nedergaard J, Cinti S, te Riele H, Kristiansen K. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc. Natl. Acad. Sci. USA 2004 101: 4112-4117

Madsen L*, Petersen RK, Sorensen MB, Jørgensen C, Hallenborg P, Pridal L, Fleckner J, Amri EZ, Krieg P, Furstenberger G, Berge RK, Kristiansen K. Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process. Biochem J. 2003 375:539-549

Petersen RK*, Jørgensen C, Rustan AC, Froyland L, Muller-Decker K, Furstenberger G, Berge RK, Kristiansen K, Madsen L. Arachidonic acid-dependent inhibition of adipocyte differentiation requires PKA activity and is associated with sustained expression of cyclooxygenases. J. Lipid. Res. 2003 44:2320-2330

Helledie T*, Jørgensen C, Antonius M, Krogsdam A-M, Kratchmarova I, Kristiansen K, Mandrup S. Role of adipocyte lipid-binding protein (ALBP) and acyl-CoA binding protein (ACBP) in PPAR-mediated transactivation. Mol. Cell. Biochem. 2002 239(1):157-64

Hansen JB*, Petersen RK*, Jørgensen C, Kristiansen K. Deregulated MAPK activity prevents adipocyte differentiation of fibroblasts lacking the retinoblastoma protein. J Biol Chem 2002 Jul 19; 277(29):26335-9

Jørgensen C*, Krogsdam AM, Kratchmarova I, Willson TM, Knudsen J, Mandrup S, Kristiansen K. Opposing effects of fatty acids and acyl-CoA esters on conformation and cofactor recruitment of peroxisome proliferator-activated receptors. Ann N Y Acad Sci 2002 Jun; 967:431-9

Elholm M*, Dam I*, Jørgensen C*, Krogsdam AM, Holst D, Kratchmarova I, Gottlicher M, Gustafsson JA, Berge R, Flatmark T, Knudsen J, Mandrup S, Kristiansen K. Acyl-CoA esters antagonize the effects of ligands on peroxisome proliferator-activated receptor alpha conformation, DNA binding, and interaction with Co-factors. J Biol Chem 2001 Jun 15; 276(24):21410-6

*1st authorship; ** Corresponding