Publications

Garofalo M, Croce CM. Role of microRNAs in maintaining cancer stem cells. Adv Drug Deliv Rev. 2015. 81C:53-61.

Garofalo M, Di Leva G, Croce CM. MicroRNAs as Anti-Cancer Therapy. Curr Pharm Des. 2014. 20(33):5328-35.

Di Leva G, Garofalo M, Croce CM. MicroRNAs in cancer. Annu Rev Pathol. 2014. 9:287-314.

Folcik VA, Garofalo M, Coleman J, Donegan JJ, Rabbani E, Suster S, Nuovo A, Magro CM, Di Leva G, Nuovo GJ. Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri. Mod Pathol. 2014. 27:851-62.

Garofalo M, Jeon YJ, Nuovo G J, Midddleton J, Joshi P, Nazaryan N, Romano G, Di Leva G,Nana-Sinkam P, Croce CM. MiR-34a/c-dependent PDGFR-α/β downregulation inhibits tumorigenesis and enhances TRAIL-induced apoptosis in lung cancer. Plos One. 2013. 8:e67581.

Calore F, Lovat F, Garofalo M. Non-coding RNAs and cancer. Int J Mol Sci. 2013. 14:17085-110.

Garofalo M, Carlo M. Croce. MicroRNAs as therapeutic targets in chemoresistance. Drug Resist Updat. 2013.16:47-59.

Acunzo M, Romano G, Palmieri D, Laganá A, Garofalo M, Balatti V, Drusco A, Chiariello M, Nana-Sinkam P, Croce CM. Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2. Proc Natl Acad Sci U S A. 2013.110:8573-8.

Nuovo A J, Garofalo M, Mikhail A, Nicol A F, Nuovo GJ. The effect of aging of formalin fixed paraffin embedded tissues on the in situ hybridization and immunohistochemistry signals in cervical lesions. Diagnostic Molecular Pathology. 2013.22:164-73.

Di Leva G, Piovan C, Gasparini P, Ngankeu A, Taccioli C, Briskin D, Cheung D G, Bolon B; Anderlucci L, Alder H, Nuovo GJ, Li M, Iorio MV, Santhanam R, Powell KA, Brasatz A, Garofalo M, Nephew KP, Croce CM. MiR-191/425 Cluster-mediated Reprograming Impairs Tumourigenicity and Metastatic Potential of Highly Aggressive Breast Cancer Cells. PLoS Genet. 2013. 9:e1003311.

Kang HW, Crawford M, Fabbri M, Nuovo G, Garofalo M, Nana-Sinkam P, Friedman A. A Mathematical Model for miR-9, let-7, and EMT in Lung Cancer". PLoS One. 2013. 8:e53663.

Quintavalle C , Donnarumma E, Iaboni M, Roscigno G, Garofalo M, Romano G, Mangani D, De Marinis P , Croce CM, Condorelli G. Effect of miR-21 and miR-30b/c on TRAIL induced apoptosis in glioma cells. Oncogene. 2013 Aug 22;32(34):4001-8.

Romano G, Acunzo M, Garofalo M, Di Leva G, Cascione L, Zanca C, Bolon B, Condorelli G, Croce CM. MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in NSCLC though BIM downregulation. Proc Natl Acad Sci U S A. 2012. 109:16570-5.

Nuovo G, Garofalo M , Valeri N, Roulstone V, Volinia S, Cohn D, Phelps M, Harrington K, Vile R, Melcher M, Galanis E, Sehl S, Coffey M. Reovirus-associated dysregulation of microRNA-let 7d is related to the increased apoptotic death of cancer cells. Mod Pathol. 2012. 25:1333-44.

Garofalo M, Quintavalle C, Condorelli G. MiR221/222 in cancer: their role in tumor progression and response to therapy. Curr. Mol. Med. 2012. 12:27-33.

Quintavalle C, Garofalo M, Zanca C, Romano G, Iaboni M, Del basso de Caro M, Incoronato M, Nuovo G, Croce CM, Condorelli G. MiR-221/222 regulate cell motility in glioma cell lines targeting the protein phosphates PTPμ. Oncogene. 2012. 31:858-68.

Acunzo M, Visone R, Romano G, Veronese A, Lovat F, Palmieri D, Consiglio J, Gasparini P, Garofalo M, Condorelli G, Chiariello M, Croce C.M. miRNA-130a downregulates miRNA-221 and miRNA-222 expression in NSCLC by targeting c-Met. Oncogene. 2012. 31:634-42.

Quintavalle C, Garofalo M, Croce CM, Condorelli G. "ApoptomiRs" in vascular cells: their role in physiological and pathological angiogenesis. Vascul Pharmacol. 2011. 55:87-91.

Garofalo M, Romano G, Di Leva G, Nuovo G, Jeon Y J, Ngankeu A., Sun J, Lovat F, Alder H, Condorelli G, Engelman J, Ono M, Rho JK, Cascione L, Volinia S, Nephew KP, Croce CM. EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat. Med. 2011. 18:74-82.

Quintavalle C, Garofalo M, Croce CM and Condorelli G. MiRNAs involved in cell survival and cell death in vascular cells. Vascul Pharmacol. 2011. 55:87-91.

Garofalo M, Croce CM. microRNAs: Master Regulators as Potential Therapeutics in Cancer. Annu Rev Pharmacol Toxicol. 2011. 51:25-43.

Quintavalle C, Incoronato M, Puca L , Acunzo M , Zanca C , Romano G, Garofalo M, Iaboni M, Croce CM and Condorelli G. c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3b activity. Cell Death Differ. 2010. 17:1908-16.

Pichiorri F, Suh S.S, Rocci A, De Luca L, Taccioli C, Ramasamy S, Wenchao Z, Lin HJ, Benson D, Hofmainster C, Garofalo M, Di Leva G, Volinia S, Alder H, Zanesi N, Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM. Down-regulation of p53-inducible microRNAs 192, 194 and 215 impairs p53/HDM2 auto-regulatory loop in multiple myeloma development. Cancer Cell. 2010.18:367-81.

Di Leva G, Gasparini P, Piovan C, Ngankeu A, Garofalo M, Taccioli C, Iorio MV, Li M, Volinia S, Alder H, Nakamura T, Nuovo G, Liu Y, Nephew K, and Croce CM. A Regulatory "miRcircuitry" involving miR-221&222 and ER-α determines ER-α status of breast cancer cells. J Natl Cancer Inst., 2010. 102:706-21.

Volinia S, Galasso M, Costinean S, Tagliavini L, Gamberoni G, Drusco A, Marchesini J, Mascellani N, Sana M E, Abu Jarour R, Desponts C, Teitell M, Baffa R, Aqeilan R, Nickoloff B,Taccioli C, Garzon R, Di Leva G, Fabbri M, Catozzi M, Previati M, Ambs S, Palumbo T, Garofalo M,et al. Reprogramming of miRNA networks in cancer and leukemia. Genome Research. 2010.5:589-99.

Incoronato M, Garofalo M, Urso L , Romano G, Quintavalle C, Zanca C, Iaboni M, Nuovo G, Croce CM and Condorelli G. miR-212 increases TRAIL sensitivity in non-small cell lung cancer by targeting the anti-apoptotic protein PED. Cancer Res. 2010. 70:3638-46.

Garofalo M, Condorelli GL, Croce CM, Condorelli G. MicroRNAs as regulators of death receptors signaling. Cell Death Differ. 2010. 17:200-8.

Garofalo M, Di Leva G, Romano G, Nuovo G, Suh SS, Ngankeu A, Taccioli C, Pichiorri F, Alder H, Secchiero P, Gasparini P, Gonelli A, Costinean S, Acunzo M, Condorelli G, Croce CM. MiR-221&222 regulate TRAIL-resistance and enhance tumorigenicity through PTEN and TIMP3 down-regulation. Cancer Cell. 2009.16:498-509.

Garofalo M, Quintavalle C, Zanca C, De Rienzo A, Romano G, Acunzo M, Puca L, Croce CM and Condorelli G. Akt regulates drug-induced cell death through Bcl-w. PLoS One. 2008.3:e4070.

Garofalo M, Condorelli G, Croce CM. MicroRNAs in diseases and drug response. Curr Opin Pharmacol. 2008. 8:661-7.

Garofalo M, Quintavalle C, Di Leva G, Zanca C, Romano G, Taccioli C, Liu CG, Croce CM, Condorelli G. MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer. Oncogene. 2008. 27:3845-55.

Garzon R∗, Garofalo M∗, Martelli MP, Briesewitz R, Wang L, Fernandez-Cymering C, Volinia S, Liu CG, Schnittger S, Haferlach T, Liso A, Diverio D, Mancini M, Meloni G, Foa R, Martelli MF, Mecucci C, Croce CM, Falini B. Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci U S A. 2008. 105:3945-50. (∗ equal contribution).

Zanca C∗, Garofalo M∗, Quintavalle C, Romano G, Acunzo M, Ragno P, Montuori N, Incoronato MR, Tornillo L, Baumhoer D, Briguori C, Terracciano L, Condorelli G. PED is overexpressed and mediates TRAIL resistance in human non-small cell lung cancer. J Cell Mol Med. 2008.12:2416-26. (∗ equal contribution).

Garofalo M, Romano G, Quintavalle C, Romano MF, Chiurazzi F, Zanca C, Condorelli G. Selective inhibition of PED protein expression sensitizes B-cell chronic lymphocytic leukaemia cells to TRAIL-induced apoptosis. Int J Cancer. 2007. 120:1215-22.

Stassi G∗, Garofalo M∗, Zerilli M, Ricci-Vitiani L, Zanca C, Todaro M, Aragona F, Limite G, Petrella G, Condorelli G. PED mediates AKT-dependent chemoresistance in human breast cancer cells. Cancer Res. 2005. 65:6668-75. (∗ equal contribution).