Selected Publications
Porter AP, White GRM, Mack NA, Malliri A. (2019)
The interaction between CASK and the tumour suppressor Dlg1 regulates mitotic spindle orientation in mammalian epithelia.
Journal of Cell Science 132(14) jcs230086. PubMed abstract
Woroniuk A, Porter A, White G, Newman DT, Diamantopoulou Z, Waring T, Rooney C, Strathdee D, Marston DJ, Hahn KM, Sansom OJ, Zech T, Malliri A. (2018)
STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.
Nature Communications 9(1):2124. PubMed abstract
Diamantopoulou Z, White G, Fadlullah MZH, Dreger M, Pickering K, Maltas J, Ashton G, MacLeod R, Baillie GS, Kouskoff V, Lacaud G, Murray GI, Sansom OJ, Hurlstone AFL, Malliri A. (2017)
TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells.
Cancer Cell, 31(5):621-634.e6. PubMed abstract
Marei H, Carpy A, Woroniuk A, Vennin C, White G, Timpson P, Macek B and Malliri A. (2016) Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.
Nature Communications (7):10664-79. PubMed abstract
Whalley HJ, Porter A, White GRM, Diamantopoulou Z, Castañeda-Saucedo E and Malliri A. (2015) Cdk1 phosphorylation of the Rac activator Tiam1 is required for centrosomal Pak activation and regulation of spindle assembly in mitosis.
Nature Communications (6):7437-51. PubMed abstract
Vaughan L, Tan C, Chapman A, Nonaka D, Mack NA, Smith D, Booton R, Hurlstone AF and Malliri A. (2015)
HUWE1 ubiquitylates and degrades the RAC Activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.
Cell Reports (10):88-102. PubMed abstract
Castillo-Lluva S, Tan CT, Daugaard M, Sorensen PH and Malliri A. (2013)
The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation.
Oncogene (32):1735-42. PubMed abstract
Mack NA, Porter AP, Whalley HJ, Schwarz JP, Jones RC, Khaja AS, Bjartell A, Anderson KI and Malliri A. (2012)
β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity.
Nature Cell Biology (14):1169-80. PubMed abstract
Castillo-Lluva S, Tatham MH, Jones RC, Jaffray EG, Edmondson RD, Hay RT and Malliri A. (2010)
SUMOylation of the GTPase Rac1 is required for optimal cell migration.
Nature Cell Biology (12):1078-85. PubMed abstract
Rooney C, White G, Nazgiewicz A, Woodcock SA, Anderson KI, Ballestrem C and Malliri A. (2010)
The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly.
EMBO Reports (11):292-98. PubMed abstract
Malliri A, van der Kammen RA, Clark K, van der Valk M, Michiels F and Collard JG. (2002)
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.
Nature (417):867-71. PubMed abstract