a PhD in copper metabolism at the University of Utrecht (the Netherlands), I started my postdoctoral career in 2008 at
the CRUK Beatson Institute in Glasgow in Karen Vousden’s lab. I obtained a personal Rubicon fellowship from the
NWO (a Dutch scientific organisation) to work on mutant p53 function in metastasis for three years. This project resulted
in a publication in Cell in 2009 and allowed for an extension of my postdoctoral position on an AICR grant with Karen
Vousden for two years. I continued my career with a Sir Henry Dale fellowship from the Wellcome Trust/Royal Society in
2013 at the MRC Toxicology Unit on the function of mutant p53 in chemoresistance. I received an early career award from
the Biochemical Society in 2015.
- PhD (2008), University of Utrecht, Department of Metabolic and Endocrine Diseases, Utrecht, the Netherlands
- Title: Transcriptomics and molecular approaches to dissect copper metabolism and the role of COMMD proteins in cellular function
Areas of Expertise
(Mutant) p53 function, cell migration and invasion, chemoresistance, copper toxicity
Aschauer L, Muller PA. (2016)
Novel targets and interaction partners of mutant p53 gain-of-function.
Biochemical Society Transactions 44(2):460-6. PubMed Abstract
Muller PA*, K. Vousden.* (2014)
Mutant p53 in cancer : New functions and therapeutic opportunites.
Cancer Cell 25(3):304-17. PubMed Abstract *Corresponding author
Muller PA*, Trinidad AG, Caswell PT, Norman JC, Vousden KH. (2014)
Mutant p53 regulates Dicer through p63 dependent and independent mechanisms to promote an invasive phenotype.
Journal of Biological Chemistry 289(1):122-32. PubMed Abstract *Corresponding author
Tan EH, Morton JP, Timpson P, Tucci P, Melino G, Flores ER, Sansom OJ, Vousden KH, Muller PA. (2014)
Functions of TAp63 and p53 in restraining the development of metastatic cancer.
Oncogene 33(25):3325-33. PubMed Abstract
Trinidad AG, Muller PA, Cuellar J, Klejnot M, Valpuesta JM, Vousden KH. (2013)
Interaction with the CCT complex promotes protein folding and WT p53 activity.
Molecular Cell 50(6):805-17. PubMed Abstract
Muller PA, Trinidad AG, Caswell P, Noll JE, Coffill CR, Lane DP, Neilsen PM, Norman JC, Vousden KH. (2013)
Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.
Oncogene 32(10):1252-65. PubMed Abstract
Muller PA, Vousden KH. (2013)
p53 mutations in cancer.
Nature Cell Biology 15(1):2-8. PubMed Abstract
Muller PA*, Coffill CR*, Hogue KA, Cheok CF, Oh HK, Neo SP, Vousden KH, Lane DP, Blackstock WP, Gunaratne HJ. (2012)
Mutant p53 interactome reveals nardilysin as a p53R273H-specific binding partner involved in invasion.
EMBO Reports 13(7):638-44. PubMed Abstract *joint first author
Muller PA*, Vousden KH, Norman JC.* (2011)
p53 and its mutants in tumor cell migration and invasion.
Journal of Cell Biology 192(2):209-18. PubMed Abstract *corresponding author
Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH. (2009)
Mutant p53 drives invasion by promoting integrin recycling.
Cell 139(7):1327-41. PubMed Abstract