Our Research

Research at the CRUK Manchester Institute spans the whole spectrum of cancer research, from programmes investigating the molecular and cellular basis of cancer, to those focused on translational research and the development of novel therapeutic approaches.  The Institute works in close collaboration with The Christie and is a partner in the Manchester Cancer Research Centre.

Our aim is to gain a greater understanding of the fundamental basis of how cancer develops and apply that knowledge to develop new diagnostic tests, potential treatments and better ways to predict the outcomes.

We have first class translational research facilities to support current activities and develop into new areas such as molecular pathology. One of the laboratories meets Good Clinical Laboratory Practice standards, and this improves our ability to assess clinical samples from early phase trial patients under the strict regulations which are now required.

Our links with industry are also being strengthened, especially in the translational and clinical research areas. For instance, an alliance with AstraZeneca has resulted in joint initiatives in biomarker research and training opportunities. Being on site at Alderley Park has also facilitated new relationships with local bioscience companies.

 

CRUK Manchester Institute Research Groups

 

Director
Caroline Dive
Cancer Biomarker Centre
 
Deputy Director
Iain Hagan
Cell Division
 

 

Esther Baena
Prostate Oncobiology
 
Claus Jørgensen
Systems Oncology
 
Angeliki Malliri
Cell Signalling
 
Tim Somervaille
Leukaemia Biology
 
Santiago Zelenay
Cancer Inflammation and Immunity
 
Rob Bristow
Translational Oncogenomics
 
Georges Lacaud
Stem Cell Biology
 
Richard Marais
Molecular Oncology
 
Caroline Springer
Director
Drug Discovery
 

Institute Fellows

Patricia Muller
Tumour Suppressors
 
Amaya Viros
Skin Cancer and Ageing
 
Maximiliano Portal
Cell Plasticity & Epigenetics
 

Team Leads

Cancer Biomarker Centre

Kris Frese
Preclinical Pharmacology
 
Alastair Kerr
Bioinformatics and Biostatistics
 
Elaine Kilgour
Cells and Proteins
 
Dónal Landers
digital Experimental Cancer Medicines Team (dECMT)
 
Carlos Lopez-Garcia
Lung Cancer Centre of Excellence Fellow
 
Dominic Rothwell
Nucleic Acids Biomarkers
 
Kathryn Simpson
Preclinical Pharmacology
 

Drug Discovery Unit

Dan Niculescu-Duvaz
Medicinal Chemistry
 
Graeme Thomson
Biology