Animals in Research
Animals in Research
Use of Animals in Our Research
Most of our research does not involve animals but some animal research is essential if we are to understand, prevent and cure cancer.
Cancer Research UK only supports the use of animals when there is no alternative. To find out more, you can read the CRUK policy on animal research and the benefits of this research for cancer patients.
As part of The University of Manchester, we are also committed to its policy on the ethical and responsible use of animals in research.
At the Cancer Research UK Manchester Institute, we use mice. In 2023, we used 6223 mice in basic research, and 6817 mice as part of programmes for the breeding and maintenance of genetically altered (GA) mice, all as part of regulated procedures under the UK Animals (Scientific Procedures) Act 1986.
We breed some strains ourselves and obtain others from suppliers who are licensed to supply animals for research. Most of the mice we use have altered genetics, which enables us to study and identify the genetic basis of different cancers and target ways in which these might be treated.
Our goal is to translate our discoveries in laboratory mice into effective treatments for cancer patients.
The animal studies we conduct are regulated under -and need to be compliant with – a piece of Legislation called the UK Animals (Scientific Procedures) Act 1986:
- A member of our senior management team holds the legal authority for our Institute; this role is known as the Establishment Licence Holder
- Our Research Group Leaders hold Project Licence authorities for their research
- All scientists and technologists involved with animal studies hold Personal Licences and receive training to assure their competence
Animal Welfare and Ethical Review Body
The welfare of our mice is a primary concern. All scientific projects involving animals are also subject to formal ethical review by the Animal Welfare and Ethical Review Body (AWERB). Our scientists receive guidance and support from our Named Animal Care and Welfare Officers, our Named Veterinary Surgeon, our Named Training and Competency Officer and our Named Information Officers.
We keep up to date on advances in the 3Rs for example through the UK National Centre for Replacement, Refinement and Reduction of animals in research
Roles of the AWERB
The AWERB exists to advise the Establishment Licence Holder (ELH) and all staff within the Establishment, including others at The University of Manchester who also work in the Paterson Building or Oglesby Cancer Research Building who use the animal research facility at Cancer Research UK Manchester Institute.
The AWERB also provides advice and oversight over the conduct of the animal research including retrospective reviews of activity of all Project Licences. In addition, the AWERB promotes the application of the 3Rs and a Culture of Care.
Advise
Provides a forum for discussion and development of ethical advice to the establishment licence holder on all matters relating to animal welfare, care and use
Promote
Promotes awareness of animal welfare and the 3Rs
Support
Supports the named people and staff working with animals, on animal welfare and ethical issues
Care
Helps to promote a 'Culture of Care'
The Concordat on Openness on Animal Research
As signatories to the Concordat on Openness on Animal Research in the UK, we welcome the opportunity to discuss and explain our research. You can contact us using the form below.