Research Themes
Research Themes
Explore some of the major themes across our research groups
The key theme of research at the CRUK Manchester Institute is cellular heterogeneity in cancer: from mechanism to clinic. Our research spans the whole spectrum of cancer research including, but not limited to, tumour-host interactions, microenvironment, biophysical regulation of tumour function, and genetic and non-genetic drivers of tumour evolution and response to therapy.
Acute myeloid leukemia (AML)
Human acute myeloid leukaemias (AMLs) are heterogeneous with respect to both genetics and the function of the cells that make up the disease.
Lung Cancer
Small cell lung cancer (SCLC) is an aggressive, highly metastatic, and incurable neuroendocrine cancer.
Pancreatic Cancer
Pancreatic Ductal Adenocarcinoma (PDA) is a dismal disease with an average five-year survival rate of 9%. PDA is the 11th most common cancer in the UK but the fourth largest contributor to cancer related deaths.
Skin cancer
Most skin cancer deaths and skin cancer complications affect the elderly, and mortality due to skin cancer is specifically increasing in the elderly.