Genome Editing and Mouse Models

The Genome Editing and Mouse Models (GEMM) facility is a core service dedicated to generating novel genetically engineered mice.

We specialise in providing comprehensive genome editing services and developing precise mouse models to advance cancer research.

GEMM offers an all-inclusive service from conceptualisation through model generation and validation.

Our services cover every step, from targeting design to confirmation of germline transmission.

This includes:

• Generation of genetically modified mice via CRISPR-Cas technology, random transgenesis and embryonic stem cell targeting
• Identification of correct genome edited alleles (Sanger sequencing and long reads sequencing)
• Cryopreservation of mouse embryos and gametes
• Import and export of mouse models from and to collaborators outside CRUK MI and repositories
• Assisted reproductive technologies (e.g. in-vitro fertilization and rederivation)
• Colony management and complex genotyping design