2025 Annual Report

Annual Report 2025 11th November 2026

Overview

Our annual Scientific Reports detail the activities of each research group, describing their publications and research projects for the year. It also contains information about technical and operational activities and our funding streams.

The latest Scientific Report highlights an incredible year of growth for the Institute and many research successes. We welcomed a new Director, Samra Turajlić to the Institute, and saw the establishment of three new independent research groups.

Major research findings were released as an impressive collection of scientific publications. These include investigations on the reasons for increased melanoma aggression in older patients, the pathways of blood formation in embryos that could help us generate fully functional blood stem cells in the lab, and the effectiveness of topical therapies to overcome immunotherapy resistance and restore anti-tumour immunity.

Find the stories from each of our lab growths from a year of advancement in the full report below.

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Annual Report 2025

2025 Annual Report

11 November 2026

https://www.sciencedirect.com/science/article/pii/S2666634026003387?via%3Dihub

Bacteria inside kidney tumors associate with myeloid inflammation and disease progression: A TRACERx Renal study

23 October 2026

Institute Authors (1)

Samra Turajlić

Research Group

Cancer Dynamics

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https://royalsocietypublishing.org/rsob/article/16/8/260089/482862/CDK1-Cyclin-B-mediated-phosphorylation-of-PP2A-B56

CDK1-Cyclin B mediated phosphorylation of PP2A-B56 on B56Par1.T73T75 controls mitotic entry timing and Schizosaccharomyces pombe cell size

19 August 2026

Institute Authors (3)

Lenka Halova, Duncan Smith, Iain Hagan

Labs & Facilities

Biological Mass Spectrometry

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Research Group

Cell Division

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https://www.cell.com/immunity/fulltext/S1074-7613(26)00278-5

CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity

4 August 2026

Institute Authors (10)

Erin Richardson, Shih-Chieh Chiang, Massimo Russo, Charles Earnshaw, Anna Pidoux, Poppy Dunn, Sudhakar Sahoo, Antonia Banyard, Natalia Moncaut, Santiago Zelenay

Labs & Facilities

BRU Experimental Team, Computational Biology Support, Genome Editing and Mouse Models, Mass and Flow Cytometry, Transgenic Breeding Team

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Research Group

Cancer Inflammation and Immunity

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https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2

Plasma signals of lung tumor promotion for molecular cancer prevention

25 June 2026

Institute Authors (1)

William Hill

Research Group

Cancer Origins

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https://link.springer.com/article/10.1038/s44319-026-00809-1

PKMYT1 has an important role in the timing and fidelity of chromosome segregation

5 June 2026

Institute Authors (6)

Asma Belbelazi, Charlie Greenaway-Wells, Zoe Edwards, Wendy Trotter, Keren Dawson, Iain Hagan

Research Group

Cell Division

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