Welcome to the Cancer Research UK Manchester Institute
World class basic, translational and clinical research

The Cancer Research UK Manchester Institute is a leading cancer research institute within The University of Manchester, core funded by Cancer Research UK, the largest independent cancer research organisation in the world.

Research spans the whole spectrum of cancer research, from programmes investigating the molecular and cellular basis of cancer, to those focused on translational research and the development of therapeutics.  The Institute (previously known as The Paterson Institute for Cancer Research) is based in the Paterson Building which is adjacent to The Christie NHS Foundation Trust.

Our Institute has recently become a partner in the CRUK Centre of Excellence for Lung Cancer and is a key part of the Belfast-Manchester Movember Centre of Excellence for Prostate Cancer.

Our Latest Publications    See More


Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation
Tape C, Ling S, Dimitriadi M, McMahon K, Worboys J, Leong HS, Norie I, Miller C, Poulogiannis G, Lauffenburger DL, Jørgensen C.
Cell (2016) 165(4). AOP Open Access
Reciprocal signalling explained

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.
Marei H, Carpy A, Woroniuk A, Vennin C, White G, Timpson P, Macek B, Malliri A.
Nat Commun. 2016 Feb 18;7:10664. doi: 10.1038/ncomms10664.