Welcome to the Cancer Research UK Manchester Institute
World class research from basic through to clinical
 
 
 

The Cancer Research UK Manchester Institute is a leading cancer research institute within The University of Manchester, core funded by Cancer Research UK, the largest independent cancer research organisation in the world.

Research spans the whole spectrum of cancer research, from programmes investigating the molecular and cellular basis of cancer, to those focussed on translational research and the development of therapeutics.  The Institute (previously known as The Paterson Institute for Cancer Research) is based in the Paterson Building which is adjacent to the Christie NHS Foundation Trust.

Our Latest Publications    See More

BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells by Reactivating MEK and ERK Signaling
Berta Sanchez-Laorden, Amaya Viros, Maria Romina Girotti, Malin Pedersen, Grazia Saturno, Alfonso Zambon, Dan Niculescu-Duvaz, Samra Turajlic, Andrew Hayes, Martin Gore, James Larkin, Paul Lorigan, Martin Cook, Caroline Springer, and Richard Marais.
Sci Signal. 2014 Mar 25;7(318):ra30. doi: 10.1126/scisignal.2004815

A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.
Jude JG, Spencer GJ, Huang X, Somerville TD, Jones DR, Divecha N, Somervaille TC.
Oncogene. 2014 Mar 31. doi: 10.1038/onc.2014.77. [Epub ahead of print]