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Latest Publications

Mackay HL, Moore D, Hall C, Birkbak NJ, Jamal-Hanjani M, Karim SA, Phatak VM, Piñon L, Morton JP, Swanton C, Le Quesne J, Muller PAJ. (2018)
Genomic instability in mutant p53 cancer cells upon entotic engulfment.
Nat Communications 9(1):3070. PubMed abstract

Torres-Ayuso P, Sahoo S, Ashton G, An E, Simms N, Galvin M, Leong HS, Frese KK, Simpson K, Cook N, Hughes A, Miller CJ, Marais R, Dive C, Krebs MG, Brognard J. (2018)
Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin.
NPJ Genomic Medicine 3:15. PubMed abstract

Lallo A, Frese KK, Morrow C, Szczepaniak Sloane R, Gulati S, Schenk MW, Trapani F, Simms N, Galvin M, Brown S, Hodgkinson CL, Priest L, Hughes AM, Lai Z, Cadogan EB, Khandelwal G, Simpson KL, Miller C, Blackhall FH, O'Connor MJ, Dive C. (2018)
The combination of the PARP inhibitor olaparib and the Wee1 inhibitor AZD1775 as a new therapeutic option for small cell lung cancer.
Clinical Cancer Research [Epub 25 June] PubMed abstract

Thambyrajah R, Fadlullah MZH, Proffitt M, Patel R, Cowley SM, Kouskoff V, Lacaud G. (2018)
HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition.
Stem Cell Reports 10(4):1369-1383. PubMed abstract

Woroniuk A, Porter A, White G, Newman DT, Diamantopoulou Z, Waring T, Rooney C, Strathdee D, Marston DJ, Hahn KM, Sansom OJ, Zech T, Malliri A. (2018)
STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.
Nature Communications 9(1):2124. PubMed abstract

Hudson AM, Stephenson NL, Li C, Trotter E, Fletcher AJ, Katona G, Bieniasz-Krzywiec P, Howell M, Wirth C, Furney S, Miller CJ, Brognard J. (2018)
Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases.
Science Signaling 11(526) pii: eaan6776. PubMed abstract

Maiques-Diaz A, Spencer GJ, Lynch JT, Ciceri F, Williams EL, Amaral FMR, Wiseman DH, Harris WJ, Li Y, Sahoo S, Hitchin JR, Mould DP, Fairweather EE, Waszkowycz B, Jordan AM, Smith DL, Somervaille TCP. (2018)
Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia.
Cell Reports 22(13):3641-3659. PubMed abstract

Böttcher JP, Bonavita E, Chakravarty P, Blees H, Cabeza-Cabrerizo M, Sammicheli S, Rogers NC, Sahai E, Zelenay S, Reis e Sousa C.
NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control.
Cell [ePub 8 February 2018] Article

Somerville TDD, Simeoni F, Chadwick JA, Williams EL, Spencer GJ, Boros K, Wirth C, Tholouli E, Byers RJ, Somervaille TCP. (2018)
Derepression of the iroquois homeodomain transcription factor gene IRX3 confers differentiation block in acute leukemia.
Cell Reports 22(3):638-652. PubMed abstract

Draper JE, Sroczynska P, Fadlullah MZH, Patel R, Newton G, Breitwieser W, Kouskoff V, Lacaud G. (2018)
A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects.
PLoS Genetics 14(1):e1007127. PubMed abstract

Valpione S, Gremel G, Mundra P, Middlehurst P, Galvani E, Girotti MR, Lee RJ, Garner G, Dhomen N, Lorigan PC, Marais R. (2018)
Plasma total cell-free DNA (cfDNA) is a surrogate biomarker for tumour burden and a prognostic biomarker for survival in metastatic melanoma patients.
European Journal of Cancer 88:1-9. PubMed abstract

Lee RJ, Gremel G, Marshall A, Myers KA, Fisher N, Dunn J, Dhomen N, Corrie PG, Middleton MR, Lorigan P, Marais R. (2017)
Circulating tumor DNA predicts survival in patients with resected high risk stage II/III melanoma.
Annals of Oncology [Epub ahead of print] PubMed abstract

Molgora M, Bonavita E, Ponzetta A, Riva F, Barbagallo M, Jaillon S, Popović B, Bernardini G, Magrini E, Gianni F, Zelenay S, Jonjić S, Santoni A, Garlanda C, Mantovani A. (2017)
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.
Nature 551(7678):110-114. PubMed abstract

Chan KY, Alonso-Nuñez M, Grallert A, Tanaka K, Connolly Y, Smith DL, Hagan IM. (2017)
Dialogue between centrosomal entrance and exit scaffold pathways regulates mitotic commitment.
Journal of Cell Biology 216(9):2795-2812. PubMed abstract

Edwards ZC, Trotter EW, Torres-Ayuso P, Chapman P, Wood HM, Nyswaner K, Brognard J. (2017)
Survival of head and neck cancer cells relies upon LZK kinase-mediated stabilization of mutant p53.
Cancer Research 77(18):4961-4972. PubMed abstract

Stefanska M, Batta K, Patel R, Florkowska M, Kouskoff V, Lacaud G. (2017)
Primitive erythrocytes are generated from hemogenic endothelial cells.
Science Reports 7(1):6401. PubMed abstract

Mould DP, Bremberg U, Jordan AM, Geitmann M, Maiques-Diaz A, McGonagle AE, Small HF, Somervaille TCP, Ogilvie D. (2017)
Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1.
Bioorganic & Medicinal Chemistry Letters 27(14):3190-3195. PubMed abstract

Draper JE, Sroczynska P, Leong HS, Fadlullah MZH, Miller C, Kouskoff V, Lacaud G. (2017)
Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors.
Blood 130(3):271-284. PubMed abstract

Chiu A, Ayub M, Dive C, Brady G, Miller CJ. (2017)
twoddpcr: An R/Bioconductor package and Shiny app for Droplet Digital PCR analysis.
Bioinformatics 33(17):2743-2745. PubMed abstract

Khandelwal G, Girotti MR, Smowton C, Taylor S, Wirth C, Dynowski M, Frese KK, Brady G, Dive C, Marais R, Miller C. (2017)
Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models.
Molecular Cancer Research 15(8):1012-1016. PubMed abstract

Tang H, Leung L, Saturno G, Viros A, Smith D, Di Leva G, Morrison E, Niculescu-Duvaz D, Lopes F, Johnson L, Dhomen N, Springer C, Marais R. (2017)
Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.
Nature Communications doi: 10.1038/ncomms14909. PubMed abstract

Diamantopoulou Z, White G, Fadlullah MZH, Dreger M, Pickering K, Maltas J, Ashton G, MacLeod R, Baillie GS, Kouskoff V, Lacaud G, Murray GI, Sansom OJ, Hurlstone AFL, Malliri A. (2017)
TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.
Cancer Cell 31(5):621-634. PubMed abstract

Carter L, Rothwell DG, Mesquita B, Smowton C, Leong HS…Miller C, Hughes A, Blackhall F, Dive C, Brady G. (2017)
Molecular analysis of circulating tumor cells identifies distinct copy-number profiles in patients with chemosensitive and chemorefractory small-cell lung cancer.
Nature Medicine 23(1):114-119.PubMed abstract