Selected Publications
Deb G, Wingelhofer B, Amaral FMR, Maiques-Diaz A, Chadwick JA, Spencer GJ, Williams EL, Leong HS, Maes T, Somervaille TCP.
Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia.
Leukemia [Epub 28 November 2019] PubMed abstract
Maiques-Diaz A, Spencer GJ, Lynch JT, Ciceri F, Williams EL, Amaral FMR, Wiseman DH, Harris WJ, Li Y, Sahoo S, Hitchin JR, Mould DP, Fairweather EE, Waszkowycz B, Jordan AM, Smith DL, Somervaille TCP. (2018)
Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia.
Cell Reports 22(13):3641-3659. PubMed abstract
Somerville TDD, Simeoni F, Chadwick JA, Williams EL, Spencer GJ, Boros K, Wirth C, Tholouli E, Byers RJ, Somervaille TCP. (2018)
Derepression of the iroquois homeodomain transcription factor gene IRX3 confers differentiation block in acute leukemia.
Cell Reports 22(3):638-652. PubMed abstract
Wiseman DH, Williams EL, Wilks DP, Sun Leong H, Somerville TD, Dennis MW, Struys EA, Bakkali A, Salomons GS, Somervaille TC. (2016)
Frequent reconstitution of IDH2 R140Q mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia.
Leukemia 30:1946-1950. Article
Somerville TD, Wiseman DH, Spencer GJ, Huang X, Lynch JT, Leong HS, Williams EL, Cheesman E, Somervaille TC. (2015)
Frequent derepression of the mesenchymal transcription factor gene FOXC1 in acute myeloid leukaemia. Cancer Cell 14:329-342. PubMed abstract
Wiseman DH, Struys EA, Wilks DP, Clark CI, Dennis MW, Jansen EE, Salomons GS, Somervaille TC. (2015)
Direct comparison of quantitative digital PCR and 2-hydroxyglutarate enantiomeric ratio for IDH mutant allele frequency assessment in myeloid malignancy.
Leukemia 29:2421-23. Article
Wiseman DH, Small HF, Wilks DP, Waddell ID, Dennis MW, Ogilvie DJ, Somervaille TC. (2014)
Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment.
British Journal of Haematology 166:145-148. Abstract
Huang X, Spencer GJ, Lynch JT, Ciceri F, Somerville TD, Somervaille TC. (2014)
Enhancers of Polycomb EPC1 and EPC2 prevent accumulation of MYC and sustain the oncogenic potential of MLL leukemia stem cells.
Leukemia 28:1081-1091. PubMed abstract
Harris WJ, Huang X, Lynch JT, Spencer GJ, Hitchin JR, Li Y, Ciceri F, Blaser JG, Greystoke BF, Jordan AM, Miller CJ, Ogilvie DJ, Somervaille TC. (2012)
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.
Cancer Cell 21:473-487. PubMed abstract
Wang Z, Smith KS, Murphy M, Piloto O, Somervaille TC, Cleary ML. (2008)
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.
Nature 405:1205-1209. PubMed abstract