Overview
Our annual Scientific Reports detail the activities of each research group, describing their publications and research projects for the year. It also contains information about technical and operational activities and our funding streams.
The latest Scientific Report highlighted a significant period for our Institute as we made the long-anticipated return to the Paterson Building, our brand-new research facility on the Christie NHS Foundation Trust site. Here you can find out how our staff continued to excel in all aspects of Institute life and reconnected with the wider scientific community within the Manchester Cancer Research Centre.
Our annual Scientific Reports detail the activities of each research group, describing their publications and research projects for the year. It also contains information about technical and operational activities and our funding streams.
The latest Scientific Report highlighted a significant period for our Institute as we made the long-anticipated return to the Paterson Building, our brand-new research facility on the Christie NHS Foundation Trust site. Here you can find out how our staff continued to excel in all aspects of Institute life and reconnected with the wider scientific community within the Manchester Cancer Research Centre.
Scientific Publications
https://doi.org/10.1038/s41420-025-02582-x
Mutant p53 induces SH3BGRL expression to promote cell engulfment
1 July 2025
Institute Authors (5)
Garry Ashton, John Weightman, Wolfgang Breitwieser, Sudhakar Sahoo, Antonia Banyard
Labs & Facilities
Computational Biology Support, Flow Cytometry, Molecular Biology
1 July 2025
https://doi.org/10.1016/j.celrep.2025.115603
Functional characterisation of the ATOH1 molecular subtype indicates a pro-metastatic role in small cell lung cancer
27 May 2025
Institute Authors (2)
Caroline Dive, Kathryn Simpson
Research Group
Small Cell Lung Cancer Biology
27 May 2025
https://doi.org/10.1016/j.ccell.2025.04.001
Stromal lipid species dictate melanoma metastasis and tropism
24 April 2025
Institute Authors (5)
Amaya Viros, Duncan Smith, Garry Ashton, Alex Baker, Tim Somervaille
Labs & Facilities
Biological Mass Spectrometry, Histology, Visualisation, Irradiation and Analysis
Research Group
Skin Cancer & Ageing
24 April 2025
https://doi.org/10.1038/s41467-025-58343-y
A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma
4 April 2025
Institute Authors (4)
Carlos Lopez-Garcia, Robert Sellers, Sudhakar Sahoo, Caroline Dive
Labs & Facilities
Computational Biology Support
Research Group
Translational Lung Cancer Biology
4 April 2025
https://doi.org/10.1186/s12943-024-02157-x
The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer
12 November 2024
Institute Authors (1)
Amaya Viros
Labs & Facilities
Genome Editing and Mouse Models
Research Group
Skin Cancer & Ageing
12 November 2024
https://doi.org/10.1186/s13045-024-01610-0
The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency
8 October 2024
Institute Authors (6)
Georges Lacaud, Mathew Sheridan, Michael Lie-a-ling, Liam Clayfield, Jessica Whittle, Jingru Xu
Research Group
Stem Cell Biology
8 October 2024