Gary Spencer
Senior Scientific Officer
Groups
Publications
- Therapeutic targeting of EP300/CBP bybromodomain inhibition in hematologicmalignancies.
- Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
- Enhancer activation by pharmacologic displacement of LSD1 from GFI1 induces differentiation in acute myeloid leukemia
- Frequent derepression of the mesenchymal transcription factor gene FOXC1 in acute myeloid leukaemia
- The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells