Selected Publications
Payapilly A, Guilbert R, Descamps T, White G, Magee P, Zhou C, Kerr A, Simpson KL, Blackhall F, Dive C, Malliri A. (2021)
TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change.
Cell Reports 37(6):109979. PubMed abstract (PMID: 34758330)
Porter AP, Reed H, White GRM, Ogg EL, Whalley HJ, Malliri A. (2021)
The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels.
Journal of Cell Science 134(7):jcs252502. PubMed abstract (PMID: 33758078)
Porter AP, White GRM, Mack NA, Malliri A. (2019)
The interaction between CASK and the tumour suppressor Dlg1 regulates mitotic spindle orientation in mammalian epithelia.
Journal of Cell Science 132(14) jcs230086. PubMed abstract
Woroniuk A, Porter A, White G, Newman DT, Diamantopoulou Z, Waring T, Rooney C, Strathdee D, Marston DJ, Hahn KM, Sansom OJ, Zech T, Malliri A. (2018)
STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.
Nature Communications 9(1):2124. PubMed abstract
Diamantopoulou Z, White G, Fadlullah MZH, Dreger M, Pickering K, Maltas J, Ashton G, MacLeod R, Baillie GS, Kouskoff V, Lacaud G, Murray GI, Sansom OJ, Hurlstone AFL, Malliri A. (2017)
TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells.
Cancer Cell, 31(5):621-634.e6. PubMed abstract
Marei H, Carpy A, Woroniuk A, Vennin C, White G, Timpson P, Macek B and Malliri A. (2016) Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.
Nature Communications (7):10664-79. PubMed abstract
Whalley HJ, Porter A, White GRM, Diamantopoulou Z, Castañeda-Saucedo E and Malliri A. (2015) Cdk1 phosphorylation of the Rac activator Tiam1 is required for centrosomal Pak activation and regulation of spindle assembly in mitosis.
Nature Communications (6):7437-51. PubMed abstract
Vaughan L, Tan C, Chapman A, Nonaka D, Mack NA, Smith D, Booton R, Hurlstone AF and Malliri A. (2015)
HUWE1 ubiquitylates and degrades the RAC Activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.
Cell Reports (10):88-102. PubMed abstract
Mack NA, Porter AP, Whalley HJ, Schwarz JP, Jones RC, Khaja AS, Bjartell A, Anderson KI and Malliri A. (2012)
β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity.
Nature Cell Biology (14):1169-80. PubMed abstract
Castillo-Lluva S, Tatham MH, Jones RC, Jaffray EG, Edmondson RD, Hay RT and Malliri A. (2010)
SUMOylation of the GTPase Rac1 is required for optimal cell migration.
Nature Cell Biology (12):1078-85. PubMed abstract
Malliri A, van der Kammen RA, Clark K, van der Valk M, Michiels F and Collard JG. (2002)
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.
Nature (417):867-71. PubMed abstract