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Computational Biology Support

Overview

The Computational Biology Support team (CBS) provides bioinformatics support and collaborative data analysis solutions to researchers across the CRUK Manchester Institute. Our core activities reside at the interface between biology, computer science and statistics, particularly in the application of high-throughput omics technologies. The primary goal of the CBS team is to build and maintain an infrastructure that enables the application of advanced bioinformatics analysis to cutting-edge scientific research within CRUK MI.

A major aspect of our work has been to develop pipelines and computational approaches for analysing high-throughput datasets generated from next generation sequencing (NGS) and mass-spectrometry platforms. Most of the workflows that we developed utilise a combination of open-source and custom-built software tools running on the on-site high performance computing facility provided by the Scientific Computing team. Working closely with the SciCom team, we are currently building automated pipelines to handle routine tasks associated with the pre-processing of deep sequencing dataset, freeing valuable time for the more challenging downstream analysis and results interpretation.

Services

We offer data analysis support to a wide range of NGS and proteomics applications, including RNA-seq, ChIP-seq, small RNA-seq, whole genome sequencing, whole exome sequencing, targeted re-sequencing, genome-wide CRISPR/Cas9 knockout screen, protein identification and label-free quantitative proteomics. In addition to these, we also provide custom support to tasks such as re-analysis of published or public domain data (e.g. TCGA), data submission to public data repositories, generating preliminary results for grant writing.

We encourage users interested in using our service to get in touch and discuss their requirements with us in advance. This allows us to assist in the design of experiments and provide the most effective data analysis solution for the project.

Team members

Wolfgang Breitwieser

  • Head of Computational Biology Support Team

Sudhakar Sahoo

  • Principal Computational Biologist

Dave Lee

  • Senior Computational Biologist

Robert Sellers

  • Senior Computational Biologist