Overview
Diet has emerged as a significant environmental factor influencing cancer progression, yet the specific dietary compounds driving these effects remain poorly understood. Pre-clinical studies have shown that palmitic acid-enriched diets can promote cancer dissemination in mice. However, the impact of other common nutrients on cancer cell behavior remains largely unexplored. We use xenotransplantation models and multimodal molecular profiling techniques, combined with diverse bioinformatics approaches, centred around RNA biology (i.e., proteomics, RNA-seq, Nanopore-seq) to understand how changes in nutrient composition intake affect the chemical deposition of RNA modifications in the tumour.
