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Stromal lipid species dictate melanoma metastasis and tropism

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Stromal lipid species dictate melanoma metastasis and tropism 24 April 2025

Gurung et al. show that young subcutaneous adipocytes provide lipids and phosphatidylcholine to melanoma cells, which activates PI3K-AKT, OXPHOS, and oxidative stress. High OXPHOS reduces metastatic burden and associates with lung tropism. Conversely, aged subcutaneous adipocytes provide ceramides to melanoma cells, which activates S1P-STAT3-IL-6 signaling, increasing total metastatic burden and liver metastasis.

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Vitamin D regulates microbiome-dependent cancer immunity

29 October 2024

PDF Document

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A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids 25 October 2024

Below et al. describe a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture.

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RNA Dynamics in Cancer

RNA Dynamics in Cancer

Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response

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