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Stromal lipid species dictate melanoma metastasis and tropism
24 April 2025
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Vitamin D regulates microbiome-dependent cancer immunity
29 October 2024
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A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids
25 October 2024
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13 September 2024
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2023 Newsletter
18 December 2024
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Featured Publication
Stromal lipid species dictate melanoma metastasis and tropism 24 April 2025
Gurung et al. show that young subcutaneous adipocytes provide lipids and phosphatidylcholine to melanoma cells, which activates PI3K-AKT, OXPHOS, and oxidative stress. High OXPHOS reduces metastatic burden and associates with lung tropism. Conversely, aged subcutaneous adipocytes provide ceramides to melanoma cells, which activates S1P-STAT3-IL-6 signaling, increasing total metastatic burden and liver metastasis.
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  • Cancer Immunosurveillance
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  • Cell Division
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  • Leukaemia Immunology & Transplantation
  • RNA Dynamics in Cancer
  • Skin Cancer & Ageing
  • Small Cell Lung Cancer Biology
  • Stem Cell Biology
  • Systems Oncology
  • Translational Lung Cancer Biology
  • Translational Oncogenomics
Featured Publication
Vitamin D regulates microbiome-dependent cancer immunity
29 October 2024
PDF Document
Download
Facilities
Facilities Overview
  • Introduction & Vision
  • Core Facilities Team
  • Sustainability
  • Animals in Research
Core Facilities
  • Biological Mass Spectrometry
  • BRU Experimental Team
  • Computational Biology Support
  • Flow Cytometry
  • Genome Editing and Mouse Models
  • Histology
  • IT and Scientific Computing
  • Lab Services
  • Logistics
  • Molecular Biology
  • Visualisation, Irradiation and Analysis
Featured Publication
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids 25 October 2024
Below et al. describe a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture.
See all publications >
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Featured Publication
2023 Annual Report 13 September 2024
See all publications >
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Core Facilities
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  • BRU Experimental Team
  • Computational Biology Support
  • Flow Cytometry
  • Genome Editing and Mouse Models
  • Histology
  • Biological Mass Spectrometry
  • BRU Experimental Team
  • Computational Biology Support
  • Flow Cytometry
  • Genome Editing and Mouse Models
  • Histology
Featured Publication
2023 Newsletter 18 December 2024
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