PhD opportunity in Cancer Dynamics group
Now open for applications – close 28 November 2025 at 1700 hrs
PhD opportunity in Cancer Dynamics group
Now open for applications – close 28 November 2025 at 1700 hrs
"Engineering and Targeting Recurrent Aneuploidy in Cancer using a novel method"
We are pleased to announce this exciting postgraduate opportunity within the Cancer Dynamics research group for intake in October 2026!
We welcome applications from enthusiastic and ambitious candidates with a strong academic track record to our PhD programme. Applicants should hold or expect to graduate with a First or minimum upper-second class undergraduate honours degree (or equivalent from a non-UK university) in a relevant subject and Masters-level and/or other laboratory research experience in cancer. Laboratory research experience as part of, or outside of, a university degree course or a Master-level degree in a relevant subject is advantageous but is not a conditional requirement in making an application.
Applications close on 28 November 2025 at 17:00 hrs
PhD Studentship
PhD Studentship
Key details
Project title: “Engineering and Targeting Recurrent Aneuploidy in Cancer using a novel method”
Supervisor: Samra Turajlić
Research Group: Cancer Dynamics
Deadline: 28 November 2025 at 1700hrs
Key objectives
- Model Establishment – Establish normal kidney and ccRCC organoids from fresh surgical specimens
- Genetic Engineering – Generate isogenic aneuploidy organoid models using CRISPRt and other genetic engineering techniques
- Characterisation – Apply multiomics profiling and functional assays to characterise the pro-tumour roles of chromosome 3(p), 9(p) and 14(q) loss
- Co-culture establishment with immune cells to investigate the role of cGAS/STING signalling and immunosuppression in metastases
- Therapeutic Development – Rational design and validate novel therapeutic based on the characterisation data and perform CRISPR or drug screens to identify additional therapeutic vulnerabilities and synthetic lethal interactions.
Ready to apply?
To apply for this studentship please complete the online application through our secure PhD Student Recruitment portal, which you can access by clicking the “Apply Now” button.
All applications will be considered equally irrespective of ethnicity, disability, sexual orientation, gender, religion/belief, age and nationality. To help the CRUK Manchester Institute monitor equality, diversity and inclusion, you will be asked to complete and submit an EDI monitoring form during the application process. Equal opportunities information will not be shared and will not form any part of the selection process or divulged to members of the selecting, recruiting or interview panels.
Please ensure you submit your application before 1700 hrs (BST) on the closing date.
Closing date: 28 November 2025
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