acute myeloid leukemia (AML)

Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer.

Resistance to chemotherapy is the most common cause of treatment failure in AML and drug efflux pump ABCB1 is a critical mediator. We established an experimental system and analysis pipeline to determine whether promoter translocations account for high ABCB1 expression in cases of relapsed human AML.