Catozzi et al. describe the ATOH1 SCLC molecular subtype contributing to SCLC heterogeneity. Like ASCL1 and NEUROD1, ATOH1 regulates neurogenesis. ATOH1 is associated with chemoresistance and is essential for tumor cell survival. ATOH1 supports aggressive tumor growth, including liver metastasis.

This year was a significant period for our Institute as we made the long-anticipated return to the Paterson Building, our brand-new research facility on the Christie NHS Foundation Trust site. Find out how our staff continued to excel in all aspects of Institute life and reconnected with the wider scientific community within the Manchester Cancer Research Centre.