Authors show systemic UVR exposure increases circulating regulatory T cells and induces an immunosuppressive signature within colorectal and melanoma mouse tumors, thereby impairing the efficacy of immunotherapy.

MANIFEST (Multiomic ANalysis of Immunotherapy Features Evidencing Success and Toxicity) aims to build a robust platform of standardised biomarkers that will help predict response, resistance and toxicity and contribute to optimise the use of current and future immunotherapies.