Gurung et al. show that young subcutaneous adipocytes provide lipids and phosphatidylcholine to melanoma cells, which activates PI3K-AKT, OXPHOS, and oxidative stress. High OXPHOS reduces metastatic burden and associates with lung tropism. Conversely, aged subcutaneous adipocytes provide ceramides to melanoma cells, which activates S1P-STAT3-IL-6 signaling, increasing total metastatic burden and liver metastasis.

Institute researchers explain age-related metastasis in melanoma. Published in Cancer Cell, the Skin Cancer & Ageing team show how lipids influence metastasis and tropism, with implications for therapy.

Authors describe a biobank of CDX models, including CDX pairs generated pretreatment and at disease progression. The CDX biobank provides a research resource to facilitate SCLC personalised medicine.