Dr Amaya Viros, head of Skin Cancer and Ageing, spoke to The Telegraph newspaper for an article "Working towards a skin cancer-free future" which explores how Dr Viros and her team aim to understand and prevent the spread of cancer in different patients.

Gurung et al. show that young subcutaneous adipocytes provide lipids and phosphatidylcholine to melanoma cells, which activates PI3K-AKT, OXPHOS, and oxidative stress. High OXPHOS reduces metastatic burden and associates with lung tropism. Conversely, aged subcutaneous adipocytes provide ceramides to melanoma cells, which activates S1P-STAT3-IL-6 signaling, increasing total metastatic burden and liver metastasis.

Institute researchers explain age-related metastasis in melanoma. Published in Cancer Cell, the Skin Cancer & Ageing team show how lipids influence metastasis and tropism, with implications for therapy.

Authors describe a biobank of CDX models, including CDX pairs generated pretreatment and at disease progression. The CDX biobank provides a research resource to facilitate SCLC personalised medicine.