This study represents a comprehensive description of the genomic landscape of ccRCC by utilising a large cohort of WGS samples that incurs a limitation to the analysis. While authors did not identify any new mutational signatures, analysis provides further support for tobacco smoking being a risk factor for ccRCC.

Using joint genomic–transcriptomic analysis of 243 samples, authors reveal recurrent patterns of nongenetic evolution in ccRCC not exclusively governed by genetic factors, including T-cell depletion, tumor T-cell receptor coevolution, and increased cell proliferation.