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2023 Annual Report
13 September 2024
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Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations
19 April 2022
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A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids
25 October 2024
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2023 Newsletter
18 December 2024
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Featured Publication
2023 Annual Report 13 September 2024
See all publications >
Research
Research Overview
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  • Cancer Immunosurveillance
  • Cancer Inflammation and Immunity
  • Cell Division
  • Leukaemia Biology
  • Leukaemia Immunology & Transplantation
  • RNA Dynamics in Cancer
  • Skin Cancer & Ageing
  • Small Cell Lung Cancer Biology
  • Stem Cell Biology
  • Systems Oncology
  • Translational Lung Cancer Biology
  • Translational Oncogenomics
Featured Publication
Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations 19 April 2022
Cytotoxic therapies, besides directly provoking cancer cell death, can also stimulate immune-dependent tumour growth control or paradoxically accelerate tumour progression. Here, the authors show that all chemotherapy drugs acutely upregulate COX-2 and PGE2 production in cancer cells with pre-existing COX-2 activity and, in doing so, fuel cancer immune escape post-treatment.
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Facilities
Facilities Overview
  • Introduction & Vision
  • Core Facilities Team
  • Sustainability
  • Animals in Research
Core Facilities
  • Biological Mass Spectrometry
  • BRU Experimental Team
  • Computational Biology Support
  • Flow Cytometry
  • Genome Editing and Mouse Models
  • Histology
  • IT and Scientific Computing
  • Lab Services
  • Logistics
  • Molecular Biology
  • Visualisation, Irradiation and Analysis
Featured Publication
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids 25 October 2024
Below et al. describe a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture.
See all publications >
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News & Events
Latest Overview
  • News
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  • Annual Report
  • Seminars
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  • International Conferences
Core Facilities
  • Biological Mass Spectrometry
  • BRU Experimental Team
  • Computational Biology Support
  • Flow Cytometry
  • Genome Editing and Mouse Models
  • Histology
  • Biological Mass Spectrometry
  • BRU Experimental Team
  • Computational Biology Support
  • Flow Cytometry
  • Genome Editing and Mouse Models
  • Histology
Featured Publication
2023 Newsletter 18 December 2024
See all publications >
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