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Stromal lipid species dictate melanoma metastasis and tropism

24 April 2025

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Vitamin D regulates microbiome-dependent cancer immunity

29 October 2024

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A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids

25 October 2024

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13 September 2024

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18 December 2024

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Featured Publication

Stromal lipid species dictate melanoma metastasis and tropism 24 April 2025

Gurung et al. show that young subcutaneous adipocytes provide lipids and phosphatidylcholine to melanoma cells, which activates PI3K-AKT, OXPHOS, and oxidative stress. High OXPHOS reduces metastatic burden and associates with lung tropism. Conversely, aged subcutaneous adipocytes provide ceramides to melanoma cells, which activates S1P-STAT3-IL-6 signaling, increasing total metastatic burden and liver metastasis.

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Cancer Immunosurveillance
Cancer Inflammation and Immunity
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Cell Division
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Leukaemia Immunology & Transplantation
RNA Dynamics in Cancer

Skin Cancer & Ageing
Small Cell Lung Cancer Biology
Stem Cell Biology
Systems Oncology
Translational Lung Cancer Biology
Translational Oncogenomics

Featured Publication

Vitamin D regulates microbiome-dependent cancer immunity

29 October 2024

PDF Document

Download

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Facilities Overview

Introduction & Vision
Core Facilities Team
Sustainability
Animals in Research

Core Facilities

Biological Mass Spectrometry
BRU Experimental Team
Computational Biology Support
Flow Cytometry
Genome Editing and Mouse Models
Histology

IT and Scientific Computing
Lab Services
Logistics
Molecular Biology
Visualisation, Irradiation and Analysis

Featured Publication

A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids 25 October 2024

Below et al. describe a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture.

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2023 Annual Report 13 September 2024

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2023 Newsletter 18 December 2024

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Luciano Nicosia

Postdoctoral Scientist

Cancer Research UK Manchester Institute
The University of Manchester
Wilmslow Road
Manchester M20 4BX

Telephone 0161 306 0871
Email enquiries@cruk.manchester.ac.uk

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