MI/25/32 Scientific Officer

Key Details

Job ID:
MI/25/32
Role:
Scientific Officer
Salary:
£23,342 – £30,000 dependent upon experience
Closing date:
25th August 2025

About the role

We are currently looking for a Scientific Officer within the Cancer Origins group. The Cancer Origins group studies how environmental exposures alter selection pressures in the lung to drive cancer using in vivo models, functional assays and single cell analysis.

The aim of this post is to to carry out research, develop projects and support the on-going research of the group. The SO will also support the efficient and effective day-to-day running and organisation of the laboratory, and ensure maintenance of equipment and supplies.

About you

You should have a BSc in Biological Sciences or related subject or equivalent relevant experience. Experience in a research laboratory setting and in cancer biology is essential. Previous experience with in vivo models along with experience with cell culture is desirable but not essential.

Photograph of Dr William Hill
Fluorescent staining of lung cells, stained green
Paterson Building Scientific Administration

More information

William Hill

William leads the Cancer Origins group which is interested in how environmental carcinogens perturb tissue homeostasis to drive tumour initiation, with a specific focus on lung cancer.

Cancer Origins

The Cancer Origins group is dedicated to understanding how cancer begins, specifically, how oncogenic cells overcome normal tissue restraints, gain malignant potential, and initiate tumour formation.

We are interested in how environmental exposures, such as air pollutants, shape the tissue microenvironment to support the expansion of latent oncogenic cells and promote lung cancer.

Lung cancer remains the leading cause of cancer-related death in both men and women, responsible for over 1.8 million deaths globally each year. While smoking has long been recognized as a primary risk factor, a growing body of evidence highlights air pollution as an increasingly significant driver of lung cancer. As smoking rates decline and global pollution levels rise, the number of lung cancer deaths linked to air pollution has increased, rising by nearly 30% since 2007.

To address these questions, we utilise genetically engineered mouse models, multiple real-world and source-specific environmental exposures, single-cell approaches, advanced imaging techniques, and 3D in vitro culture systems. By working with exceptional collaborators, we aim to translate these findings into new strategies for preventing and treating human disease, ultimately improving patient outcomes.

About CRUK Manchester Institute

Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials. rnThe Institute has access to outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry.

William Hill
Cancer Origins
About CRUK Manchester Institute

How to apply

How to apply?

To apply for this position please complete the online application by clicking ‘Apply Now’ button to visit our secure job application site. Please ensure you detail the names of two referees and ensure you submit your application before the closing date specified.

 

Please note this vacancy will close for applications at 11:59pm on the closing date specified.

Contact us for further information

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Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute, an Institute of The University of Manchester, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org),
the largest independent cancer research organisation in the world.

We are partnered with The Christie NHS Foundation Trust, one of the largest cancer treatment centres in Europe, which is located adjacent to the CRUK MI Manchester Institute in South Manchester. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

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