Key Details
About the role
Dr Claus Jorgensen, Group Leader of the Systems Oncology Group, is looking for a Postdoctoral Scientist to join his group. This is a great opportunity for a self-motivated, innovative, meticulous and organised candidate who is keen to work in a dynamic laboratory undertaking cutting edge research.
The goal of the Systems Oncology Group is to understand how the tumour microenvironment, and the desmoplastic reaction, regulates tumour cell function and therapeutic response in pancreatic ductal adenocarcinoma. We have identified a novel target regulating the interactions between tumour cells and the microenvironment, which we believe may be a target for future therapeutic intervention.
The objective of this post is to functionally characterise this target and its role in regulating tumour cells, host cells, and their interactions. Specifically, the post holder will use a number of in vitro cell biology assays to assess cell function and biochemical assays to assess cell signalling in vitro; this will include functional CRISPR analysis, pharmacological studies, enzyme assays and mass spectrometry analysis in 2D and 3D cell models. Tumour models will be analysed by IF/IHC, proteomics, genomics and transcriptionally as well as testing novel combination treatments using available in vivo models (see Hutton et al Cancer Cell 2021, Lee et al Nat Comm 2021 and Below et al Nat Mat 2022). This is a project for a highly collaborative individual seeking to make a difference in a very hard to treat cancer.
About you
You should have a PhD in biochemistry, cell biology or a related field. Experience in protein biochemistry, analysis of cell signalling and use of in vitro models of cancer is required. Experience with in vivo tumour models and immunology is desirable. Key qualities include independent thinking, ability to work in a team and good communication skills, all of which are needed to efficiently work in a multidisciplinary team.
More information
How to apply
To apply for this position please complete the online application via ‘Apply Now’. Please ensure you detail the names of three referees and ensure you submit your application before the closing date specified.
Please note this vacancy will close for applications at 11:59pm on the closing date specified.
Informal enquiries can be directed to Dr Claus Jorgensen via email: claus.jorgensen@cruk.manchester.ac.uk.
Closing date: Sunday 26th October 2025.
1st round interviews: w.c. 10th November 2025.
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