MI/25/57 Postdoctoral Scientist

Key Details

Job ID:
MI/25/57
Role:
Postdoctoral Scientist
Salary:
£37,000 – £44,852 (dependent upon qualifications and experience)
Closing date:
26th October 2025

About the role

A postdoctoral position is available in the laboratory of Sylvain Delaunay to study how diet affects RNA modifications to drive cancer progression.

To this end, xenotransplantation models and multimodal molecular profiling techniques will be used, combined with diverse bioinformatics approaches, centred around RNA biology (i.e., CRISPR-screen, Ribo-seq, RNA-seq, Nanopore-seq). Besides biological material coming from primary cell lines and in vivo mouse models, we will also have access to patient samples to use as discovery and validation of our findings.

About you

You are adept at problem-solving, working proactively, and meeting competing deadlines effectively. You should hold a PhD in Molecular Biology, Cell Biology, Pharmacy or a related discipline. A background in RNA biology and mRNA translation is desirable but not required. You should have an excellent academic track record for publications. You will have excellent organisational skills, strong attention to detail, and the ability to work collaboratively as part of a team. A current or previous holder of a Personal Licence (PIL A & B) or equivalent under the Animals (Scientific Procedures) Act 1986, as well as experience in CRISPR-screen is preferrable. Applications from candidates with exceptional bioinformatics skills who are eager to gain hands-on wet lab experience are also welcome.

Photo of Junior Group Leader Sylvain Delaunay
Paterson Building Scientific Administration

More information

Sylvain Delaunay

Sylvain joined the CRUK Manchester Institute in January 2025 to set up his new group, RNA Dynamics in Cancer. He is intrigued by the interplay between diet and RNA modifications in their role in plasticity in cancer cell states, in particular motility and metastasis.

RNA Dynamics in Cancer

[Brief overview of the group]

About CRUK Manchester Institute

Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials. rnThe Institute has access to outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry.

Sylvain Delaunay
RNA Dynamics in Cancer
About CRUK Manchester Institute

How to apply

To apply for this position please complete the online application via ‘Apply Now’ button to visit our secure job application site. Please ensure you detail the names of three referees and ensure you submit your application before the closing date specified.

Closing date: Sunday 26 October 2025. Please note this vacancy will close for applications at 11:59 pm on the closing date specified.

Online Interviews will take place: 10th-14th November 2025.

Contact us for further information

Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute, an Institute of The University of Manchester, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org),
the largest independent cancer research organisation in the world.

We are partnered with The Christie NHS Foundation Trust, one of the largest cancer treatment centres in Europe, which is located adjacent to the CRUK MI Manchester Institute in South Manchester. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

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