PhD opportunity in Chromatin Regulation in Cancer group
OPEN for applications – close on 3 April 2026 at 1700 hrs GMT
PhD opportunity in Chromatin Regulation in Cancer group
OPEN for applications – close on 3 April 2026 at 1700 hrs GMT
"Defining the mechanisms that establish heterochromatin and promote silencing of tumour suppressor genes using electron microscopy"
We are pleased to announce this exciting postgraduate opportunity within the Chromatin Regulation in Cancer research group for intake in October 2026!
We welcome applications from enthusiastic and ambitious candidates with a strong academic track record to our PhD programme. Applicants should hold or expect to graduate with a First or minimum upper-second class undergraduate honours degree (or equivalent from a non-UK university) in a relevant subject and Masters-level and/or other laboratory research experience in cancer. Laboratory research experience as part of, or outside of, a university degree course or a Master-level degree in a relevant subject is advantageous but is not a conditional requirement in making an application.
Applications close on 3 April 2026 at 1700 hrs GMT
Key objectives
- Combine EM with nanogold labelling to map distinct chromatin structural configurations to specific classes of heterochromatin that are marked by known epigenetic regulators
- Dissect the functional and temporal dynamics of heterochromatin assembly by labelling ERV elements in a time-course following SETDB1 overexpression
- Use CRISPR to deplete key players of heterochromatin assembly and define their roles in establishing and maintaining silent chromatin compartments
Ready to apply?
To apply for this studentship please complete the online application through our secure PhD Student Recruitment portal, which you can access by clicking the “Apply Now” button.
All applications will be considered equally irrespective of ethnicity, disability, sexual orientation, gender, religion/belief, age and nationality. To help the CRUK Manchester Institute monitor equality, diversity and inclusion, you will be asked to complete and submit an EDI monitoring form during the application process. Equal opportunities information will not be shared and will not form any part of the selection process or divulged to members of the selecting, recruiting or interview panels.
Please ensure you submit your application before 1700 hrs (GMT) on the closing date.
Closing date: 3 April 2026 1700 hrs GMT
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