Applications Closed – PhD opportunity in Chromatin Regulation in Cancer group
Update 7th April – Applications are now closed
Applications Closed – PhD opportunity in Chromatin Regulation in Cancer group
Update 7th April – Applications are now closed
"Defining the mechanisms that establish heterochromatin and promote silencing of tumour suppressor genes using electron microscopy"
We are pleased to announce this exciting postgraduate opportunity within the Chromatin Regulation in Cancer research group for intake in October 2026!
We welcome applications from enthusiastic and ambitious candidates with a strong academic track record to our PhD programme. Applicants should hold or expect to graduate with a First or minimum upper-second class undergraduate honours degree (or equivalent from a non-UK university) in a relevant subject and Masters-level and/or other laboratory research experience in cancer. Laboratory research experience as part of, or outside of, a university degree course or a Master-level degree in a relevant subject is advantageous but is not a conditional requirement in making an application.
Applications close on 6 April 2026 at 1700 hrs BST
PhD Studentship
PhD Studentship
Key details
Project title: “Defining the mechanisms that establish heterochromatin and promote silencing of tumour suppressor genes using electron microscopy”
Supervisor: Alice Sherrard
Research Group: Chromatin Regulation in Cancer
Deadline: 6 April 2026 at 1700 hrs BST
Key objectives
- Combine EM with nanogold labelling to map distinct chromatin structural configurations to specific classes of heterochromatin that are marked by known epigenetic regulators
- Dissect the functional and temporal dynamics of heterochromatin assembly by labelling ERV elements in a time-course following SETDB1 overexpression
- Use CRISPR to deplete key players of heterochromatin assembly and define their roles in establishing and maintaining silent chromatin compartments
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