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2023 Annual Report

13 September 2024

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Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations

19 April 2022

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A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids

25 October 2024

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18 December 2024

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Institute Overview

About us
Our Team
Operations
Scientific Advisory Board
Funding

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Overview
Cancer Research UK
Manchester Cancer Research Centre
The Christie NHS Foundation Trust
Commercialisation and Innovation

Careers at CRUK MI
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Newsletters

Featured Publication

2023 Annual Report 13 September 2024

See all publications >

Research

Research Overview

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Cancer Immunosurveillance
Cancer Inflammation and Immunity
Cell Division
Leukaemia Biology
Leukaemia Immunology & Transplantation
RNA Dynamics in Cancer

Skin Cancer & Ageing
Small Cell Lung Cancer Biology
Stem Cell Biology
Systems Oncology
Translational Lung Cancer Biology
Translational Oncogenomics

Featured Publication

Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations 19 April 2022

Cytotoxic therapies, besides directly provoking cancer cell death, can also stimulate immune-dependent tumour growth control or paradoxically accelerate tumour progression. Here, the authors show that all chemotherapy drugs acutely upregulate COX-2 and PGE2 production in cancer cells with pre-existing COX-2 activity and, in doing so, fuel cancer immune escape post-treatment.

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Biological Mass Spectrometry
BRU Experimental Team
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Genome Editing and Mouse Models
Histology

IT and Scientific Computing
Lab Services
Logistics
Molecular Biology
Visualisation, Irradiation and Analysis

Featured Publication

A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids 25 October 2024

Below et al. describe a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture.

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BRU Experimental Team
Computational Biology Support
Flow Cytometry
Genome Editing and Mouse Models
Histology

Biological Mass Spectrometry
BRU Experimental Team
Computational Biology Support
Flow Cytometry
Genome Editing and Mouse Models
Histology

Featured Publication

2023 Newsletter 18 December 2024

See all publications >

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Normalising the pancreatic desmoplasia

Normalising the pancreatic desmoplasia

Cancer Research UK Manchester Institute
The University of Manchester
Wilmslow Road
Manchester M20 4BX

Telephone 0161 306 0871
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