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2023 Annual Report

13 September 2024

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Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations

19 April 2022

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A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids

25 October 2024

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18 December 2024

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Institute Overview

About us
Our Team
Operations
Scientific Advisory Board
Funding

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Overview
Cancer Research UK
Manchester Cancer Research Centre
The Christie NHS Foundation Trust
Commercialisation and Innovation

Careers at CRUK MI
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Featured Publication

2023 Annual Report 13 September 2024

See all publications >

Research

Research Overview

Research Vision
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Cancer Immunosurveillance
Cancer Inflammation and Immunity
Cell Division
Leukaemia Biology
Leukaemia Immunology & Transplantation
RNA Dynamics in Cancer

Skin Cancer & Ageing
Small Cell Lung Cancer Biology
Stem Cell Biology
Systems Oncology
Translational Lung Cancer Biology
Translational Oncogenomics

Featured Publication

Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations 19 April 2022

Cytotoxic therapies, besides directly provoking cancer cell death, can also stimulate immune-dependent tumour growth control or paradoxically accelerate tumour progression. Here, the authors show that all chemotherapy drugs acutely upregulate COX-2 and PGE2 production in cancer cells with pre-existing COX-2 activity and, in doing so, fuel cancer immune escape post-treatment.

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Biological Mass Spectrometry
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Genome Editing and Mouse Models
Histology

IT and Scientific Computing
Lab Services
Logistics
Molecular Biology
Visualisation, Irradiation and Analysis

Featured Publication

A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids 25 October 2024

Below et al. describe a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture.

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BRU Experimental Team
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Genome Editing and Mouse Models
Histology

Biological Mass Spectrometry
BRU Experimental Team
Computational Biology Support
Flow Cytometry
Genome Editing and Mouse Models
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Featured Publication

2023 Newsletter 18 December 2024

See all publications >

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Telephone 0161 306 0871
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