PhD opportunity in Chromatin Regulation
We welcome applications to our PhD Programme – apply before the deadline on 6th November 2026 1700 GMT
PhD opportunity in Chromatin Regulation
We welcome applications to our PhD Programme – apply before the deadline on 6th November 2026 1700 GMT
Predicting Cell State from Chromatin Architecture to Understand Cancer Initiation and Progression
We are pleased to announce this exciting postgraduate opportunity within the Chromatin Regulation research group for intake in October 2027!
We welcome applications from enthusiastic and ambitious candidates with a strong academic track record to our PhD programme. Applicants should hold or expect to graduate with a First or minimum upper-second class undergraduate honours degree (or equivalent from a non-UK university) in a relevant subject and Masters-level and/or other laboratory research experience in cancer.
Laboratory research experience as part of, or outside of, a university degree course or a Master-level degree in a relevant subject is advantageous but is not a conditional requirement in making an application.
Applications close on 6th November 2026 at 17:00 GMT.
Key objectives
In this project, you will first work with established collaborators to generate an AI model to identify stages of differentiation from developmental and de-differentiation (induced pluripotency stem cells, iPSC) time courses of chromatin structure we have already generated.
Next, you will generate electron tomography datasets of established cancer models that capture defined stages of cancer initiation and progression and test the ability of their model to predict these stages.
Finally, you will investigate the mechanisms that drive chromatin structural changes using a combination of CRISPR mutagenesis and genomics (ChIP-seq, ATAC-seq). Integrating genomic profiling and high-resolution EM will generate a comprehensive, multi-scale model of pluripotency is established and how its dysregulation contributes to oncogenesis.
Ready to apply?
To apply for this studentship please complete the online application through our secure PhD Student Recruitment portal, which you can access by clicking the “Apply Now” button. All applications will be considered equally irrespective of ethnicity, disability, sexual orientation, gender, religion/belief, age and nationality. To help the CRUK Manchester Institute monitor equality, diversity and inclusion, you will be asked to complete and submit an EDI monitoring form during the application process. Equal opportunities information will not be shared and will not form any part of the selection process or divulged to members of the selecting, recruiting or interview panels.
Please ensure you submit your application before 1700 GMT hrs on the closing date of 6th November 2026.
Any questions? Use this form to contact our student team
Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute, an Institute of The University of Manchester, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org),
the largest independent cancer research organisation in the world.
We are partnered with The Christie NHS Foundation Trust, one of the largest cancer treatment centres in Europe, which is located adjacent to the CRUK MI Manchester Institute in South Manchester. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.
Our vision for world leading cancer research in the heart of Manchester
We are a leading cancer research institute within The University of Manchester, spanning the whole spectrum of cancer research – from investigating the molecular and cellular basis of cancer, to translational research and the development of therapeutics.
Our collaborations
Bringing together internationally renowned scientists and clinicians
Scientific Advisory Board
Supported by an international Scientific Advisory Board



