PhD opportunity in Skin Cancer and Ageing

We welcome applications to our PhD Programme – apply before the deadline on 6th November 2026 1700 GMT

Aged immune failure and reversal

We are pleased to announce this exciting postgraduate opportunity within the Skin Cancer and Ageing research group for intake in October 2027!

We welcome applications from enthusiastic and ambitious candidates with a strong academic track record to our PhD programme. Applicants should hold or expect to graduate with a First or minimum upper-second class undergraduate honours degree (or equivalent from a non-UK university) in a relevant subject and Masters-level and/or other laboratory research experience in cancer.

Laboratory research experience as part of, or outside of, a university degree course or a Master-level degree in a relevant subject is advantageous but is not a conditional requirement in making an application.

Applications close on 6th November 2026 at 17:00 GMT.

Dr Amaya Viros
Colourful immunofluorescent image of a 3D tumour-like spheroid

PhD project details

This project will be part of our investigation of how organ-specific lipid milieus impact cancer invasion, organ tropism and immunity, and the lipid species and ratios that organise the plasma membrane into functional nanodomains to control receptor clustering and modulate signalling thresholds across immune lineages. We want to study how ageing modifies the lipid composition of the extracellular milieu and how this impacts immune competence.

Amaya Virós

Prof Amaya Virós leads the Skin Cancer and Ageing Group and is also an Honorary Consultant in Dermatology at Salford NHS Foundation Trust, with a practice in general dermatology and high-risk skin cancer.

Her research aims to understand the mechanisms that drive more metastatic skin cancer in ageing patients and to develop novel therapeutic approaches for melanoma treatment by age, in metastatic organs. Amaya also leads a BRC project to develop novel biomarkers that predict skin cancer outcomes.

Skin Cancer and Ageing

The group aim to understand how host-specific factors and site-specific cues drive melanoma progression and therapeutic outcomes, and from this to to develop personalised melanoma rationales that consider the entire organism, not just the tumour itself.

Research projects are ongoing to understand the melanoma metastatic process to solid organs, and how melanoma adapts to new environments and how new sites impact the response to therapy, seeking vulnerabilities that can be targeted to change patient outcomes, reducing relapses.

Being a student at the CRUK Manchester Institute

Here at the CRUK Manchester Institute, our postgraduate students enjoy a supportive environment, while having the opportunity to sink their teeth into a challenging project alongside receiving tailored training in transferable and generic skills.rnrnThis vital combination of training and support helps our students develop as independent scientists with excellent career prospects.

PhD project details
Amaya Virós
Skin Cancer and Ageing
Being a student at the CRUK Manchester Institute

Key objectives

We want to study how ageing modifies the lipid composition of the extracellular milieu and how this impacts immune competence.

In this project you will map how ageing sculpts the systemic and organ lipidome using lipidomics, lipoprotein fractionation, spatial approaches including superresolution microscopy across tissues (under co-supervision from Dr Jonathan Worboys, Lydia Becker Institute, University of Manchester).

The project will focus particularly on lipid species and classes known to determine T cell activation quality. Beyond T cells, you will interrogate how the aged lipid environment shapes innate and adaptive immunity more broadly and contributes to tumour immunosurveillance. You will use in vivo approaches to modify the lipidome and test restoration of immune competence in antitumour immunity.

Ready to apply?

To apply for this studentship please complete the online application through our secure PhD Student Recruitment portal, which you can access by clicking the “Apply Now” button. All applications will be considered equally irrespective of ethnicity, disability, sexual orientation, gender, religion/belief, age and nationality. To help the CRUK Manchester Institute monitor equality, diversity and inclusion, you will be asked to complete and submit an EDI monitoring form during the application process. Equal opportunities information will not be shared and will not form any part of the selection process or divulged to members of the selecting, recruiting or interview panels.

Please ensure you submit your application before 1700 GMT hrs on the closing date of 6th November 2026.

Any questions? Use this form to contact our student team

Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute, an Institute of The University of Manchester, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org),
the largest independent cancer research organisation in the world.

We are partnered with The Christie NHS Foundation Trust, one of the largest cancer treatment centres in Europe, which is located adjacent to the CRUK MI Manchester Institute in South Manchester. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.