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WORLD CLASS BASIC, TRANSLATIONAL AND CLINICAL RESEARCH

DNA Repair Gene Dysfunction

We are now looking to address the mechanism by which BRCA2 mutations and dysfunction leads to genetic instability within primary prostate epithelium. Using a combination of primary human epithelial cultures and murine genetically modified mice, we are determining the relationship between BRCA2 mutation knock-in or nullizygous BRCA2 knock-out, in combination with pertinent mutated oncogenes and tumour suppressor genes, in a series of genotype-phenotype studies. Phenotypes to be investigated will include different inter- and intracellular signalling, differential DNA repair and genomic stability and affects on androgen signalling.