Publications

Vaughan L, Tan C, Chapman A, Nonaka D, Mack NA, Smith D, Booton R, Hurlstone AF, Malliri A. HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion. Cell Rep. 2014 Dec 23. pii: S2211-1247(14)01041-9. doi: 10.1016/j.celrep.2014.12.012. [Epub ahead of print]

Daugaard M, Nitsch R, Razaghi B, McDonald L, Jarrar A, Torrino S, Castillo-Lluva S, Rotblat B, Li L, Malliri A, Lemichez E, Mettouchi A, Berman JN, Penninger JM, Sorensen PH. Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nat Commun. 4:2180. (2013)

Chicooree N, Connolly Y, Tan CT, Malliri A, Li Y, Smith DL, Griffiths JR. Enhanced detection of ubiquitin isopeptides using reductive methylation. J Am Soc Mass Spectrom. 24(3):421-30. (2013)

Dalton LE, Kamarashev J, Barinaga-Rementeria Ramirez I, White G, Malliri A, Hurlstone A. Constitutive Rac Activation Is Not Sufficient to Initiate Melanocyte Neoplasia but Accelerates Malignant Progression.  J Invest Dermatol. 133(6):1572-81. (2013)

Chicooree N, Griffiths JR, Connolly Y, Tan CT, Malliri A, Eyers CE, Smith DL. A novel approach to the analysis of SUMOylation with the independent use of trypsin and elastase digestion followed by database searching utilising consecutive residue addition to lysine. Rapid Commun Mass Spectrom. 27(1):127-34. (2013)

Castillo-Lluva S, Tan CT, Daugaard M, Sorensen PH, Malliri A. The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation. Oncogene. 32(13):1735-42. (2013)

Mack NA, Porter AP, Whalley HJ, Schwarz JP, Jones RC, Khaja AS, Bjartell A, Anderson KI, Malliri A.  β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity.  Nat Cell Biol. 14(11):1169-80. (2012)

Daskalos A, Oleksiewicz U, Filia A, Nikolaidis G, Xinarianos G, Gosney JR, Malliri A, Field JK, Liloglou T. UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer. Cancer. 117:1027-1037. (2011)

Mack NA, Whalley HJ, Castillo-Lluva S, Malliri A. The diverse roles of Rac signaling in tumorigenesis. Cell Cycle. 10:1571-1581. (2011)

Castillo-Lluva S, Tatham MH, Jones RC, Jaffray EG, Edmondson RD, Hay RT, Malliri A. SUMOylation of the GTPase Rac1 is required for optimal cell migration. Nat Cell Biol. 12(11):1078-85. (2010)

Woodcock SA, Rushton HJ, Castañeda-Saucedo E, Myant K, White GR, Blyth K, Sansom OJ, Malliri ATiam1-Rac signalling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression. Curr Biol. 20:669-675. (2010)

Rooney C, White G, Nazgiewicz A, Woodcock SA, Anderson KI, Ballestrem C, Malliri A. The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly. EMBO Rep. 11: 292-298. (2010)

Woodcock SA, Jones RC, Edmondson RD, Malliri A. A modified tandem affinity purification technique identifies that 14-3-3 proteins interact with Tiam1, an interaction which controls Tiam1 stability. J Proteome Res. 8:5629-5641. (2009)

Woodcock SA, Rooney C, Liontos M, Connolly Y, Zoumpourlis V, Whetton AD, Gorgoulis VG, Malliri A. Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1. Molecular Cell. 33:639-653. (2009)

Malliri A, Rygiel TP, van der Kammen RA, Song JY, Engers R, Hurlstone AF, Clevers H, Collard JG. The Rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem. 281:543-8. (2006)

Malliri A, van Es S, Huveneers S, Collard JG. The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesions. J Biol Chem. 279:30092-30098. (2004)

Malliri A, Collard JG. Role of Rho-family proteins in cell-adhesion and cancer. Curr Opin Cell Biol. 15:583-589. (2003)

Malliri A, van der Kammen RA, Clark K, van der Valk M, Michiels F, Collard JG. (2002) Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature, 417, 867-871.

Malliri A, ten Klooster JP, Olivio C, Collard JG. (2002) Determination of the activity of Rho-like GTPases in cells. Methods Mol Biol.,189, 99-109.

Stapleton G, Malliri A, Ozanne BW. (2002) Downregulated AP-1 activity is associated with inhibition of Protein-Kinase-C-dependent CD44 and ezrin localisation and upregulation of PKC theta in A431 cells. J Cell Sci., 115, 2713-2724.

Lambert JM, Lambert QT, Reuther GW, Malliri A, Siderovski DP, Sondek J, Collard JG, Der CJ. (2002) Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol., 4, 621-625.

Evers EE, Zondag GC, Malliri A, Price LS, ten Klooster JP, van der Kammen RA, Collard JG. (2000) Rho family proteins in cell adhesion and cell migration. Eur J Cancer, 36, 1269-1274.