Publications

Batta K, Florkowska M, Kouskoff V, Lacaud G. Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells. (2014) Cell Rep. 9(5):1871-84.

Lie-A-Ling M, Marinopoulou E, Li Y, Patel R, Stefanska M, Bonifer C, Miller C, Kouskoff V, Lacaud G. RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence. (2014) Blood. 2014 Jul 31. pii: blood-2014-04-572958. [Epub ahead of print]

Perez-Campo FM, Costa G, Lie-A-Ling M, Stifani S, Kouskoff V, Lacaud G. (2014) MOZ-mediated repression of p16(INK) (4) (a) is critical for the self-renewal of neural and hematopoietic stem cells. Stem Cells, 32(6):1591-601.

Stefanska M, Costa G, Lie-A-Ling M, Kouskoff V, Lacaud G. (2014) Smooth muscle cells largely develop independently of functional hemogenic endothelium. Stem Cell Research, 12(1):222-32.

Perez-Campo FM, Costa G, Lie-a-Ling M, Kouskoff V, Lacaud G. (2013) The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis. Immunology, 139(2):161-5.

Lichtinger M, Ingram R, Hannah R, Müller D, Clarke D, Assi SA, Lie-A-Ling M, Noailles L, Vijayabaskar MS, Wu M, Tenen DG, Westhead DR, Kouskoff V, Lacaud G, Göttgens B, Bonifer C. (2012) RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis. EMBO J., 31(22):4318-33.

Wareing S, Eliades A, Lacaud G, Kouskoff V. (2012) ETV2 expression marks blood and endothelium precursors, including hemogenic endothelium, at the onset of blood development. Dev Dyn., 241(9):1454-64.

Wareing S, Mazan A, Pearson S, Göttgens B, Lacaud G, Kouskoff V. (2012) The Flk1-Cre-mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development. Stem Cells, 30(7):1521-31.

Costa, G., Kouskoff, V., and Lacaud, G. (2012). Origin of blood cells and HSC production in the embryo. Trends in immunology 33, 215-223.

Costa, G., Mazan, A., Gandillet, A., Pearson, S., Lacaud, G., and Kouskoff, V. (2012). SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development. Development 139, 1587-1598.

Lancrin, C., Mazan, M., Stefanska, M., Patel, R., Lichtinger, M., Costa, G., Vargel, O., Wilson, N.K., Moroy, T., Bonifer, C., Göttgens B, Kouskoff V, Lacaud G. (2012). GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment. Blood 120, 314-322.

Boros, K., Lacaud, G., Kouskoff, V. The transcription factor Mxd4 controls the proliferation of the first blood precursors at the onset of hematopoietic development in vitro. 2011 Experimental Hematology 39 (11), pp. 1090-1100

Ferreras, C., Lancrin, C., Lie-A-Ling, M., Kouskoff, V., Lacaud, G. Identification and characterization of a novel transcriptional target of RUNX1/AML1 at the onset of hematopoietic development. 2011 Blood 118 (3), pp. 594-597

Holley, R.J., Pickford, C.E., Rushton, G., Lacaud, G., Gallagher, J.T., Kouskoff, V., Merry, C.L.R. 2011 Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble heparin and heparan sulfate saccharides. Journal of Biological Chemistry 286 (8), pp. 6241-6252

Mazzarella, L., Jørgensen, H.F., Soza-Ried, J., Terry, A.V., Pearson, S., Lacaud, G., Kouskoff, V., Fisher, A.G. Embryonic stem cell-derived hemangioblasts remain epigenetically plastic and require PRC1 to prevent neural gene expression. 2011 Blood 117 (1), pp. 83-87

Sroczynska P, Lancrin C, Kouskoff V and Lacaud, G. (2009) The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis.Blood, Epub ahead of print.

Gandillet A, Serrano AG, Pearson S, Lie-A-Ling M, Lacaud G, Kouskoff V. (2009)Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification.Blood, Oct 2. Epub ahead of print.

Lancrin C, Sroczynska P, Serrano AG, Gandillet A, Ferreras C, Kouskoff V, Lacaud G. Blood Cell Generation from the Hemangioblast. Journal of Molecular Medicine,Epub ahead of print.

Hoogenkamp M, Lichtinger M, Krysinska H, Lancrin C, Clarke D, Williamson A, Mazzarella L, Ingram R, Jorgensen H, Fisher A, Tenen DG, Kouskoff V, Lacaud G, Bonifer C. (2009)  Early chromatin unfolding by RUNX1 - a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.  Blood, Jul 9; 114(2):299-309.

Lancrin C, Sroczynska P, Stephenson C, Allen T, Kouskoff V, Lacaud G. (2009)The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature, 457(7231):892-5.

Perez-Campo FM, Borrow J, Kouskoff V, Lacaud G. (2009) The HAT activity of MOZ is critical for the proliferation of hematopoietic precursors. Blood,113(20):4866-74.

Landry JR, Bonadies N, Kinston S, Knezevic K, Wilson NK, Oram SH, Janes M, Piltz S, Hammett M, Carter J, Hamilton T, Donaldson IJ, Lacaud G, Frampton J, Follows G, Kouskoff V, Göttgens B. (2009) Expression of the leukaemia oncogene Lmo2 is controlled by an array of tissue specific elements dispersed over 100kb and bound by Tal1/Lmo2, Ets and Gata factors.  Blood, 113(23):5783-92.

Sroczynska P, Lancrin C, Pearson S, Kouskoff V, Lacaud G. (2009) In vitro differentiation of mouse embryonic stem cells as a model of early hematopoietic development.  Methods Mol Biol, 538,  317-334. 

Pearson, S, Sroczynska, P, Lacaud G, Kouskoff, V. (2008) The step-wise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to BMP4, Activin A, FGF and VEGF. Development, 135, 1525-1535.

Williamson AJ, Smith DL, Blinco D, Unwin RD, Pearson S, Wilson C, Miller C, Lancashire L, Lacaud G, Kouskoff V, Whetton AD. (2008) Quantitative proteomic analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis.  Mol Cell Proteomics, 7, 459-472.

Baldwin RJ, ten Dam GB, van Kuppevelt TH, Lacaud G, Gallagher JT, Kouskoff V, Merry CL. (2008) A developmentally-regulated heparan sulfate epitope defines a sub-population with increased blood potential during mesodermal differentiation.  Stem Cells26, 3108-3118. 

Pimanda JE, Ottersbach K, Knezevic K, Kinston S, Chan WY, Wilson NK, Landry JR, Wood AD, Kolb-Kokocinski A, Green AR, Tannahill D, Lacaud G, Kouskoff V, Göttgens B. (2007)  Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc Natl Acad Sci U S A, 104, 17692-17697.

Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff,V, Jones N. (2007) Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev, 21, 2069-2082.

Chan WY, Follows, GA, Lacaud G, Pimanda JE, Landry JR, Kinston S, Knezevic K, Piltz S, Donaldson IJ, Gambardella L, Sablitzky F, Green AR, Kouskoff V, Gottgens B. (2006) The paralogous haemopoietic regulators Lyl1 and SCL are co-regulated by Ets and GATA factors yet Lyl1 cannot rescue the early SCL-/- phenotype. Blood,109, 1908-1916. 

Kouskoff V, Lacaud G, Schwantz S, Fehling JH, Keller G. (2005) Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation. Proc Natl Acad Sci U S A, 102(37):13170-5.

Lacaud G, Kouskoff V, Trumble A, Schwantz S, Keller G. (2004) Haploinsufficiency of Runx1 results in the acceleration of mesodermal development and hemangioblast specification upon in vitro differentiation of ES cells. Blood, 103(3): 886-9.

Lacaud G, Keller G, Kouskoff V. Tracking mesoderm formation and specification to the hemangioblast in vitro. (2004) Trends Cardiovasc Med, 2004 14(8):314-7