Latest Publications

Plastic petri dishes stained with blue dye to reveal cells grown on their surface

Giampazolias E, Pereira da Costa M, Lam KC, Lim KHJ, Cardoso A, Piot C, Chakravarty P, Blasche S, Patel S, Biram A, Castro-Dopico T, Buck MD, Rodrigues RR, Poulsen GJ, Palma-Duran SA, Rogers NC, Koufaki MA, Minutti CM, Wang P, Vdovin A, Frederico B, Childs E, Lee S, Simpson B, Iseppon A, Omenetti S, Kelly G, Goldstone R, Nye E, Suárez-Bonnet A, Priestnall SL, MacRae JI, Zelenay S, Patil KR, Litchfield K, Lee JC, Jess T, Goldszmid RS, Reis E Sousa C. (2024)
Vitamin D regulates microbiome-dependent cancer immunity.
Science 384(6694):428-437. PubMed abstract (PMID: 38662827)

Thambyrajah R, Maqueda M, Neo WH, Imbach K, Guillén Y, Grases D, Fadlullah Z, Gambera S, Matteini F, Wang X, Calero-Nieto FJ, Esteller M, Florian MC, Porta E, Benedito R, Göttgens B, Lacaud G, Espinosa L, Bigas A. (2024)
Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate.
Nat Commun.15(1):1604. PubMed abstract (PMID: 38383534)

Patterson C, Hazime KS, Zelenay S, Davis DM. (2024)
Prostaglandin E₂ impacts multiple stages of the natural killer cell anti-tumor immune response.
Eur J Immunol e2350635. PubMed abstract (PMID: 38059519)

Nicosia L, Spencer GJ, Brooks N, Amaral FMR, Basma NJ, Chadwick JA, Revell B, Wingelhofer B, Maiques-Diaz A, Sinclair O, Camera F, Ciceri F, Wiseman DH, Pegg N, West W, Knurowski T, Frese K, Clegg K, Campbell VL, Cavet J, Copland M, Searle E, Somervaille TCP. (2023)
Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies.
Cancer Cell 41(12):2136-2153.e13. PubMed abstract (PMID: 37995682)

Kas SM, Mundra PA, Smith DL, Marais R. (2023)
Functional classification of DDOST variants of uncertain clinical significance in congenital disorders of glycosylation.
Sci Rep. 13(1):17648. PubMed abstract (PMID: 37848450)

Ginn L, Maltas J, Baker MJ, Chaturvedi A, Wilson L, Guilbert R, Amaral FMR, Priest L, Mole H, Blackhall F, Diamantopoulou Z, Somervaille TCP, Hurlstone A, Malliri A. (2023)
A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells.
Proc Natl Acad Sci U S A 120(40):e2300489120. PubMed abstract (PMID: 37748077)


Qu F, Brough SC, Michno W, Madubata CJ, Hartmann GG, Puno A, Drainas AP, Bhattacharya D, Tomasich E, Lee MC, Yang D, Kim J, Peiris-Pagès M, Simpson KL, Dive C, Preusser M, Toland A, Kong C, Das M, Winslow MM, Pasca AM, Sage J. (2023)
Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis.
Nat Cell Biol. 25(10):1506-1519. PubMed abstract (PMID: 37783795)

Pearsall SM, Williamson SC, Humphrey S, Hughes E, Morgan D, García Marqués FJ, Awanis G, Carroll R, Burks L, Shue YT, Bermudez A, Frese KK, Galvin M, Carter M, Priest L, Kerr A, Zhou C, Oliver TG, Humphries JD, Humphries MJ, Blackhall F, Cannell IG, Pitteri SJ, Hannon GJ, Sage J, Dive C, Simpson KL. (2023)
Lineage Plasticity in SCLC Generates Non-Neuroendocrine Cells Primed for Vasculogenic Mimicry.
J Thorac Oncol. 18(10):1362-1385. PubMed abstract (PMID: 37455012)

Camera F, Romero-Camarero I, Revell BH, Amaral FMR, Sinclair OJ, Simeoni F, Wiseman DH, Stojic L, Somervaille TCP. (2023)
Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO.
iScience. 26(8):107319. PubMed abstract (PMID: 37539037)

Shohdy KS, Pillai M, Guest R, Rothwell D, Kirillova N, Chow S, Gilham D, Thistlethwaite F, Hawkins R. (2023)
Evidence of clinical efficacy of a first generation CD19 CAR T cell in B cell malignancies.
EJHaem. 4(3):882-885. PubMed abstract (PMID: 37601889)

Morgan RD, Clamp AR, White DJ, Price M, Burghel GJ, Ryder WDJ, Mahmood RD, Murphy AD, Hasan J, Mitchell CL, Salih Z, Wheeler C, Buckley E, Truelove J, King G, Ainaoui Y, Bhaskar SS, Shaw J, Evans DGR, Kilerci B, Pearce SP, Brady G, Dive C, O'Connor JPB, Wallace AJ, Rothwell DG, Edmondson RJ, Jayson GC. (2023)
Multi-Maintenance Olaparib Therapy in Relapsed, Germline BRCA1/2-Mutant High-Grade Serous Ovarian Cancer (MOLTO): A Phase II Trial.
Clin Cancer Res. 29(14):2602-2611. PubMed abstract (PMID: 36799931)

Oing C, Bristow RG. (2023)
Systemic treatment of metastatic hormone-sensitive prostate cancer-upfront triplet versus doublet combination therapy.
ESMO Open 8(2):101194. Link to article (PMID: 36947986)

Roberts M, Ogden J, Hossain ASM, Chaturvedi A, Kerr ARW, Dive C, Beane JE, Lopez-Garcia C. (2023)
Interrogating the precancerous evolution of pathway dysfunction in lung squamous cell carcinoma using XTABLE.
Elife 12:e77507. PubMed abstract (PMID: 36892933)

Shlyakhtina Y, Bloechl B, Portal MM. (2023)
BdLT-Seq as a barcode decay-based method to unravel lineage-linked transcriptome plasticity.
Nature Communications 14(1):1085. PubMed abstract (PMID: 36841849)

O'Regan P, Hoskins R, Grave C, Stevenson JA, Frost H, Graham DM, Krebs MG, Freitas A, Landers D.(2023)
Digital ECMT Cancer Trial Matching Tool: an Open Source Research Application to Support Oncologists in the Identification of Precision Medicine Clinical Trials.
JCO Clinical Cancer Informatics 7:e2200137. PubMed abstract (PMID: 36657092)

Wang YH, Yao CY, Lin CC, Gurashi K, Amaral FMR, Bossenbroek H, Jerez A, Somervaille TCP, Binder M, Patnaik MM, Hou HA, Chou WC, Batta K, Wiseman DH, Tien HF.
A three-gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia.
British Journal of Haematology [Epub 6 February 2023] PubMed abstract (PMID: 36746431)