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WORLD CLASS BASIC, TRANSLATIONAL AND CLINICAL RESEARCH

Latest Publications


Bonavita E, Bromley CP, Jonsson G, Pelly VS, Sahoo S, Walwyn-Brown K, Mensurado S, Moeini A, Flanagan E, Bell CR, Chiang SC, Gowda CPC, Rogers N, Silva-Santos B, Jaillon S, Mantovani A, Reis e Sousa C, Guerra N, Davis DM and Zelenay S. (2020)
Antagonistic inflammatory phenotypes dictate tumor fate and response to immune checkpoint blockade.
Immunity 53, 1–15. PubMed abstract

Williams MS, Basma NJ, Amaral FMR, Williams G, Weightman JP, Breitwieser W, Nelson L, Taylor SS, Wiseman DH, Somervaille TCP. (2020)
Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer. 
BMC Cancer 20(1):1075. PubMed abstract

Trotter EW, Hagan IM. (2020)
Release from cell cycle arrest with Cdk4/6 inhibitors generates highly synchronized cell cycle progression in human cell culture. 
Open Biol. 10(10):200200. PubMed abstract

Saturno G, Lopes F, Niculescu-Duvaz I, Niculescu-Duvaz D, Zambon A, Davies L, Johnson L, Preece N, Lee R, Viros A, Holovanchuk D, Pedersen M, McLeary R, Lorigan P, Dhomen N, Fisher C, Banerji U, Dean E, Krebs MG, Gore M, Larkin J, Marais R, Springer C. (2020)
The paradox-breaking panRAF plus SRC family kinase inhibitor, CCT3833, is effective in mutant KRAS-driven cancers. 
Ann Oncol. S0923-7534(20)42986-2. PubMed abstract

Salamero O, Montesinos P, Willekens C, Pérez-Simón JA, Pigneux A, Récher C, Popat R, Carpio C, Molinero C, Mascaró C, Vila J, Arévalo MI, Maes T, Buesa C, Bosch F, Somervaille TCP.
First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia. 
J Clin Oncol. [Epub 14 October 2020] PubMed abstract

Lee RJ, Khandelwal G, Baenke F, Cannistraci A, Macleod K, Mundra P, Ashton G, Mandal A, Viros A, Gremel G, Galvani E, Smith M, Carragher N, Dhomen N, Miller C, Lorigan P, Marais R. (2020)
Brain microenvironment-driven resistance to immune and targeted therapies in acral melanoma. 
ESMO Open 5(4):e000707. PubMed abstract

Pearsall SM, Humphrey S, Revill M, Morgan D, Frese KK, Galvin M, Kerr A, Carter M, Priest L, Blackhall F, Simpson KL, Dive C. (2020)
The Rare YAP1 Subtype of SCLC Revisited in a Biobank of 39 Circulating Tumor Cell Patient Derived Explant Models: A Brief Report. 
J Thorac Oncol. S1556-0864(20)30588-8. PubMed abstract

Paliouras AR, Buzzetti M, Shi L, Donaldson IJ, Magee P, Sahoo S, Leong HS, Fassan M, Carter M, Di Leva G, Krebs MG, Blackhall F, Lovly CM, Garofalo M. (2020)
Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition. 
EMBO Mol Med. 12(7):e11099. PubMed abstract

Trucco LD, Mundra PA, García-Martínez P, Hogan K, Baenke F, Dhomen N, Pavet V, Marais R.
Map3k1 Loss Cooperates with BrafV600E to Drive Melanomagenesis. 
J Invest Dermatol. [Epub 22 May 2020] Link to abstract

Lotz M, Budden T, Furney SJ, Virós A.
Molecular subtype, biological sex and age shape melanoma tumour evolution. 
Br J Dermatol. [Epub 13 April 2020] PubMed abstract

Valpione S, Galvani E, Tweedy J, Mundra PA, Banyard A, Middlehurst P, Barry J, Mills S, Salih Z, Weightman J, Gupta A, Gremel G, Baenke F, Dhomen N, Lorigan PC, Marais R. (2020)
Immune-awakening revealed by peripheral T cell dynamics after one cycle of immunotherapy. 
Nat Cancer 1(2):210-221. PubMed abstract

Galvani E, Mundra PA, Valpione S, Garcia-Martinez P, Smith M, Greenall J, Thakur R, Helmink B, Andrews MC, Boon L, Chester C, Gremel G, Hogan K, Mandal A, Zeng K, Banyard A, Ashton G, Cook M, Lorigan P, Wargo JA, Dhomen N, Marais R. (2020)
Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma. 
Nat Commun. 11(1):853. PubMed abstract

Deb G, Wingelhofer B, Amaral FMR, Maiques-Diaz A, Chadwick JA, Spencer GJ, Williams EL, Leong HS, Maes T, Somervaille TCP. (2020)
Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia.
Leukemia 34(5):1266-1277. PubMed abstract

Mohan S, Foy V, Ayub M, Leong HS, Schofield P, Sahoo S, Descamps T, Kilerci B, Smith NK, Carter M, Priest L, Zhou C, Carr TH, Miller C, Faivre-Finn C, Blackhall F, Rothwell DG, Dive C, Brady G. (2020)
Profiling of circulating free DNA using targeted and genome wide sequencing in patients with small cell lung cancer.
Journal of Thoracic Oncology 15(2):216-230. PubMed abstract

Smithen DA, Leung LMH, Challinor M, Lawrence R, Tang H, Niculescu-Duvaz D, Pearce SP, Mcleary R, ​Lopes F, Aljarah M, Brown M, Johnson L, Thomson G, Marais R, Springer C. (2020)
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth. 
J Med Chem. 63(5):2308-2324. PubMed abstract