Skip to content

Home
About
Research
Facilities
Operations
News & Events
Careers & Study

Institute Life
Contact Us

Search for:

Institute Overview

About us
Our Team
Operations
Scientific Advisory Board
Funding

Partnerships

Overview
Cancer Research UK
Manchester Cancer Research Centre
The Christie NHS Foundation Trust
Commercialisation and Innovation

Latest

Careers at CRUK MI
Study at CRUK MI
Publications
News
Newsletters

Featured Publication

2023 Annual Report

13 September 2024

See all publications >

Research Overview

Research Vision
Research History
Research Themes
Research Support
Publications

Research Groups

Cancer Immunosurveillance
Cancer Inflammation and Immunity
Cell Division
Leukaemia Biology
Leukaemia Immunology & Transplantation
RNA Dynamics in Cancer

Skin Cancer & Ageing
Small Cell Lung Cancer Biology
Stem Cell Biology
Systems Oncology
Translational Lung Cancer Biology
Translational Oncogenomics

Featured Publication

Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations

19 April 2022

See all publications >

Facilities Overview

Introduction & Vision
Core Facilities Team
Sustainability
Animals in Research

Core Facilities

Biological Mass Spectrometry
BRU Experimental Team
Computational Biology Support
Flow Cytometry
Genome Editing and Mouse Models
Histology

IT and Scientific Computing
Lab Services
Logistics
Molecular Biology
Visualisation, Irradiation and Analysis

Featured Publication

A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids

25 October 2024

See all publications >

Operations Overview

Overview
Research Support
Grants Support
Animal Welfare & Ethical Review Body
Education

Operations Teams

Scientific Administration
Human Resources
Finance
Health and Safety

Latest Overview

News
Newsletters
Annual Report
Seminars
Events
International Conferences

Featured Publication

2023 Newsletter

18 December 2024

See all publications >

Working at CRUK MI

Vacancies
Institute Life
Our Team
Facilities
Operations
Human Resources
Living in Manchester
Latest News

Studying at CRUK MI

Students
PhD Student Recruitment
Submit a PhD Studentship Application
PhD Application FAQs
Education Committee
Student Progression & Monitoring
Student Welfare and Community
Visiting Students
International PhD Student Cancer Conference

About

Institute Overview

About us
Our Team
Operations
Scientific Advisory Board
Funding

Partnerships

Overview
Cancer Research UK
Manchester Cancer Research Centre
The Christie NHS Foundation Trust
Commercialisation and Innovation

Careers at CRUK MI
Study at CRUK MI
Publications
News
Newsletters

Featured Publication

2023 Annual Report 13 September 2024

See all publications >

Research

Research Overview

Research Vision
Research History
Research Themes
Research Support
Publications

Research Groups

Cancer Immunosurveillance
Cancer Inflammation and Immunity
Cell Division
Leukaemia Biology
Leukaemia Immunology & Transplantation
RNA Dynamics in Cancer

Skin Cancer & Ageing
Small Cell Lung Cancer Biology
Stem Cell Biology
Systems Oncology
Translational Lung Cancer Biology
Translational Oncogenomics

Featured Publication

Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations 19 April 2022

Cytotoxic therapies, besides directly provoking cancer cell death, can also stimulate immune-dependent tumour growth control or paradoxically accelerate tumour progression. Here, the authors show that all chemotherapy drugs acutely upregulate COX-2 and PGE2 production in cancer cells with pre-existing COX-2 activity and, in doing so, fuel cancer immune escape post-treatment.

See all publications >

Facilities

Facilities Overview

Introduction & Vision
Core Facilities Team
Sustainability
Animals in Research

Core Facilities

Biological Mass Spectrometry
BRU Experimental Team
Computational Biology Support
Flow Cytometry
Genome Editing and Mouse Models
Histology

IT and Scientific Computing
Lab Services
Logistics
Molecular Biology
Visualisation, Irradiation and Analysis

Featured Publication

A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids 25 October 2024

Below et al. describe a fully synthetic hydrogel extracellular matrix designed to elicit key phenotypic traits of the pancreatic environment in culture.

See all publications >

Operations

Operations Overview

Overview
Research Support
Grants Support
Animal Welfare & Ethical Review Body
Education

Operations Teams

Scientific Administration
Human Resources
Finance
Health and Safety

News & Events

Latest Overview

News
Newsletters
Annual Report
Seminars
Events
International Conferences

Core Facilities

Biological Mass Spectrometry
BRU Experimental Team
Computational Biology Support
Flow Cytometry
Genome Editing and Mouse Models
Histology

Biological Mass Spectrometry
BRU Experimental Team
Computational Biology Support
Flow Cytometry
Genome Editing and Mouse Models
Histology

Featured Publication

2023 Newsletter 18 December 2024

See all publications >

Careers & Study

Working at CRUK MI

Vacancies
Institute Life
Our Team
Facilities
Operations
Human Resources
Living in Manchester
Latest News

Studying at CRUK MI

Students
PhD Student Recruitment
Submit a PhD Studentship Application
PhD Application FAQs
Education Committee
Student Progression & Monitoring
Student Welfare and Community
Visiting Students
International PhD Student Cancer Conference

Institute Life
Contact Us

Search for:

Characterising tumour promoting and restrictive elements in the tumour microenvironment of PDA

Characterising tumour promoting and restrictive elements in the tumour microenvironment of PDA

Cancer Research UK Manchester Institute
The University of Manchester
Wilmslow Road
Manchester M20 4BX

Telephone 0161 306 0871
Email enquiries@cruk.manchester.ac.uk

About

About CRUK MI
Our Team
Equality, Diversity and Inclusion
Sustainability
Animal Welfare and Ethical Review Body

Research

Research Groups
Our Research Teams
Publications

Careers

Post Docs
PhD Students
All Opportunities

Contact

Contact Us
Cancer Research UK

About CRUK MI
Our Team
Equality, Diversity and Inclusion
Sustainability
Animal Welfare and Ethical Review Body

Research Groups
Our Research Teams
Publications

Post Docs
PhD Students
All Opportunities

Contact Us
Cancer Research UK

© Copyright 2025. Cancer Research UK Manchester Institute. All Right Reserved.
Designed and developed by Cornerstone DM

Cookie Policy
Privacy Policy
Accessibility
Charitable Status
Freedom of Information