Multi-region sequencing reveals key aspects of tumor evolution from small numbers of patients. Authors evaluated a large cohort of localised prostate tumours to understand the population characteristics of their subclonal evolution.

Authors review hypoxia and prostate tumour progression and discuss the biochemistry of hypoxia and implications for prostate cancer, targeting of hypoxic cancer cell, rational combinations for anti-hypoxia therapy and future outlook.

Authors discuss the epidemiology, mechanisms of disease, diagnosis, screening and prevention, management, quality of life and outlook for patients with prostate cancer.

The authors looked at tissue hypoxia as an important differentiating metabolic characteristic between normal and malignant tissues. They show extensive intertumor- and intratumor-type heterogeneity in tumor hypoxia.

This year was a significant period for our Institute as we made the long-anticipated return to the Paterson Building, our brand-new research facility on the Christie NHS Foundation Trust site. Find out how our staff continued to excel in all aspects of Institute life and reconnected with the wider scientific community within the Manchester Cancer Research Centre.