Publications

Molgora M, Bonavita E, Ponzetta A, Riva F, Barbagallo M, Jaillon S, Popović B, Bernardini G, Magrini E, Gianni F, Zelenay S, Jonjić S, Santoni A, Garlanda C, and Mantovani A. 2017. IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature. 551:110–114. 

Helft J, Böttcher JP, Chakravarty P, Zelenay S, Huotari J, et al. 2016. Alive but Confused: Heterogeneity of CD11c(+) MHC Class II(+) Cells in GM-CSF Mouse Bone Marrow Cultures. Immunity. 44(1):3-4.

Zelenay S* and Reis e Sousa C*. 2016. Reducing prostaglandin E2 production to raise cancer immunogenicity. Oncoimmunology 5(5):e1123370.*Corresponding authors.

Böttcher JP, Zelenay S, Rogers N, Helft J, Schraml B and Reis e Sousa C. 2015. Oncogenic transformation of dendritic cells and their precursors leads to rapid cancer development in mice. J Immunol. 195(10):5066-76.

Zelenay S*, van der Veen AG, Böttcher JP, Snelgrove KJ, Rogers N, Acton SE, Chakravarty P, Girotti, MR, Marais R, Quezada SA, Sahai E, and Reis e Sousa C*. 2015. Cyclooxygenase-dependent tumor growth through evasion of immunity. Cell 162, 1–14.*Corresponding authors

Helft J, Böttcher J, Chakravarty P, Zelenay S, Huotari J, Schraml BU, Goubau D, and Reis e Sousa C. 2015. GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c+MHCII+ Macrophages and Dendritic Cells. Immunity 42, 1197–1211.

van Blijswijk J, Schraml BU, Rogers NC, Whitney PG, Zelenay S, et al. 2015. Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells. J Immunol 194(1):307–15.

Murillo MM, Zelenay S, Nye E, Castellano E, Lassailly F, et al. 2014. RAS interaction with PI3K p110α is required for tumor-induced angiogenesis. J Clin Invest 124(8):3601–11.

Schraml BU, van Blijswijk J, Zelenay S, Whitney PG, Filby A, Acton SE, Rogers NC, Moncaut N, Carvajal JJ, and Reis e Sousa C. 2013. Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage. Cell 154(4):843–858.

Zelenay S and Reis e Sousa C. 2013. Adaptive immunity after cell death. Trends Immunol 34(7):329–335.

Paiva RS, Lino AC, Bergman M-L, Caramalho I, Sousa AE, Zelenay S, and Demengeot J. 2013. Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery. Proc Natl Acad Sci USA 110(16):6494–6499.

Zelenay S, Keller AM, Whitney PG, Schraml BU, Deddouche S, Rogers NC, Schulz O, Sancho D, and Reis e Sousa C. 2012. The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice. J Clin Invest 122(5):1615–1627.

Ahrens S, Zelenay S, Sancho D, Hanč P, Kjær S, Feest C, Fletcher G, et al. 2012. F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells. Immunity 36(4):635–645.

Mourão-Sá D, Robinson MJ, Zelenay S, Sancho D, Chakravarty P, Larsen R, Plantinga M, et al. 2011. CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses. Eur J Immunol 41(10):3040–3053.

Caramalho I, Rodrigues-Duarte L, Perez A, Zelenay S, Penha-Gonçalves C, and Demengeot J. 2011. Regulatory T cells contribute to diabetes protection in lipopolysaccharide-treated non-obese diabetic mice. Scand J Immunol 74(6):585–595.

Zelenay S*, Bergman M-L, Paiva RS, Lino AC, Martins AC, Duarte JH, Moraes Fontes MF, Bilate AM, Lafaille JJ, and Demengeot J. 2010. Cutting edge: Intrathymic differentiation of adaptive Foxp3+ regulatory T cells upon peripheral proinflammatory immunization. J Immunol 185(7):3829–3833.  *Corresponding author.

Poulin LF, Salio M, Griessinger E, Anjos-Afonso F, Craciun L, Chen J-L, Keller AM, Joffre O, Zelenay S, Nye E, et al. 2010. Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med 207(6):1261–1271.

Joffre OP, Sancho D, Zelenay S, Keller AM, and Reis e Sousa C. 2010. Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A. Eur J Immunol 40(5):1255–1265.

Moraes-Fontes MF, Rebelo M, Caramalho I, Zelenay S, Bergman M-L, Coutinho A, and Demengeot J. 2009. Steroid treatments in mice do not alter the number and function of regulatory T cells, but amplify cyclophosphamide-induced autoimmune disease. J Autoimmun 33(2):109–120.

Duarte JH, Zelenay S, Bergman M-L, Martins AC, and Demengeot J. 2009. Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur J Immunol 39(4):948–955.

Zelenay S, Moraes Fontes MF, Fesel C, Demengeot J, and Coutinho A. 2007. Physiopathology of natural auto-antibodies: the case for regulation. J Autoimmun 29(4):229–235.

Zelenay S, Chora A, Soares MP, and Demengeot J. 2007. Heme oxygenase-1 is not required for mouse regulatory T cell development and function. Int Immunol 19(1):11–18.

Zelenay S and Demengeot J. 2006. Comment on "Cutting edge: anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells". J Immunol 177(4):2036–7– author reply 2037–8.

Demengeot J, Zelenay S, Moraes-Fontes MF, Caramalho I, and Coutinho A. 2006. Regulatory T cells in microbial infection. Springer Semin Immunopathol 28(1):41–50.

Zelenay S, Lopes-Carvalho T, Caramalho I, Moraes-Fontes MF, Rebelo M, and Demengeot J. 2005. Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci USA 102(11):4091–4096.

Zelenay S, Elías F, and Fló J. 2003. Immunostimulatory effects of plasmid DNA and synthetic oligodeoxynucleotides. Eur J Immunol 33(5):1382–1392.

Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, and Demengeot J. 2003. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 197(4):403–411.