MI/26/52 Postdoctoral Scientist

Key Details

Job ID:
MI/26/52
Role:
Postdoctoral Scientist
Salary:
£39,253 – £47,543 per annum (dependent upon qualifications and experience)
Closing date:
30th October 2026

About the role

Professor Claus Jørgensen Group Leader of the Systems Oncology Group, is looking for a Postdoctoral Scientist to join his group. This is a great opportunity for a self-motivated, meticulous and organised candidate with an interest in protein biochemistry, cell signalling and proteomics analysis to undertake a cutting-edge research question and work across an international collaboration.

The goal of the Systems Oncology Group is to understand how the tumour microenvironment, and the desmoplastic reaction in particular, regulate tumour cell signalling and therapeutic response in pancreatic ductal adenocarcinoma. The objective of this post is to learn, optimise and apply novel cutting-edge sample processing methodologies for cell specific phosphoproteomics analysis of metastatic pancreatic cancer. Specifically, you will work across the White lab (MIT, MA, USA) and Jorgensen lab (CRUK MI, UK) to learn the methodology (White lab) and apply it to PDAC 3D and in vivo samples (Jorgensen lab). The post holder is expected to interact collaboratively with members of the laboratories and contribute to the design and development of on-going research projects in support of the Systems Oncology group.

About you

You should have a PhD in biochemistry, cancer biology or a related field. Prior experience in protein biochemistry and analysis of cell signalling is essential and prior experience with (phospho) proteomics and in vivo models of cancer is beneficial. Key qualities include independent thinking, ability to work in a team and good communication skills, all of which are needed to efficiently work in a multidisciplinary team. Given the collaborative nature of the project, you are expected to spend time in both laboratories.

Claus Jørgensen Senior Group Leader
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Paterson Building Scientific Administration

More information

Claus Jorgensen

Claus is Deputy Director and a Senior Group Leader at the CRUK Manchester Institute. He heads the Systems Oncology group, which focuses on the complex interactions between malignant and normal cells, with a particular interest in pancreatic cancer.

Systems Oncology Group

We are particularly interested in the chemical messages that are sent between cells as pancreatic cancer develops. We aim to identify the key signals that drive tumour growth and help the cancer cells to spread around the body, and ultimately find new ways to block these signals – reducing tumour growth and metastatic spread. Survival from pancreatic cancer has changed little over the years; the average five-year survival rate is just 12%, thus identifying new ways to treat this disease is a real priority for the 10,000 people diagnosed each year in the UK.

About CRUK Manchester Institute

Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials. rnThe Institute has access to outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry.

Claus Jorgensen
Systems Oncology Group
About CRUK Manchester Institute

How to apply

To apply for this position please complete the online application via ‘Apply Now’. Please ensure you detail the names of three referees and ensure you submit your application before the closing date specified.

Please note this vacancy will close for applications at 18:00 on the closing date specified. Informal enquiries can be directed to Dr Claus Jorgensen via email:  claus.jorgensen@cruk.manchester.ac.uk

Closing date: 30 October 2026 Friday.

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Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute, an Institute of The University of Manchester, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org),
the largest independent cancer research organisation in the world.

We are partnered with The Christie NHS Foundation Trust, one of the largest cancer treatment centres in Europe, which is located adjacent to the CRUK MI Manchester Institute in South Manchester. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.

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