Opportunities at CRUK Manchester Institute

Welcome to our Opportunities pages where you will find information about the various roles we are able to offer at our world-renowned cancer research institute. The CRUK Manchester Institute provides state-of-the-art facilities where researchers can further develop both their science and their careers in a highly collaborative and supportive environment. 

Postdoctoral Scientist – Prostate Oncobiology

Reference Number: MI/18/104_2
Starting Salary: within the range of £31,604 - £41,929 (dependent upon qualifications and experience)
Closing Date: 13 March 2019
Duration of Post: Fixed term for 3 years

About the role:
We are looking for a highly-motivated Postdoctoral Scientist to join Dr Baena’s Prostate Oncobiology group to study the role of inflammation on prostate tumour initiation and how to prevent their progression to metastatic prostate cancer.

Prostate cancer (PCa) is the second leading cause of cancer-related mortality in men worldwide, accounting for 15% of all male cancer deaths. PCa patients exhibit a high heterogeneity both clinically and biologically highly variable clinical behaviour; some have indolent disease whilst in others it is lethal. Although the initial response to androgen deprivation therapy is almost universal, progression to castration resistant state is inevitable and lethal.

Previous work from our laboratory shows the importance of further understanding molecular events leading to castration-resistant prostate cancer as they’re key for the development of improved therapies for such patients (Barros-Silva et al., 2018; Parry et al., 2018; Baena et al., 2013).

Thus, the post holder will work on defining the role of tumour-driven inflammatory pathways, and its impact on tumour microenvironment to promote tumour-initiation and progression to castration-resistant stage. This study will provide new avenues to prevent prostate tumour progression and metastasis by molecular and immune-based interventions for prostate cancer patients.

About you:
You will have a PhD in a relevant related subject and have research laboratory experience. You will also have profound knowledge in cellular and molecular biology and have experience of working with in vivo cancer models. You will have significant experience of cell culture, particularly in vitro 3D culture systems and handling primary cells. Profound experience in FACS analyses and lineage tracing work is also essential for this position.

This is an exciting opportunity for you to be involved in developing and driving the project as well as writing up work for presentation and publication.

The Cancer Research UK Manchester Institute (, an Institute of The University of Manchester (, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (, the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.

We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK Manchester Institute, Paterson Building) in South Manchester (, one of the largest cancer treatment centres in Europe.

The CRUK Manchester Institute is a key part of the Belfast-Manchester Movember Centre of Excellence for Prostate Cancer. As well as bringing together expert researchers and clinicians, the Movember Centres of Excellence will also provide a world-class training ground for the scientists of the future, building a legacy of top prostate cancer researchers in the UK, as well as establishing international collaborations for the brightest minds to tackle the most important questions in prostate cancer research – now and into the future.

How to apply?
To apply for this position please complete an equal opportunities form and submit along with a CV and accompanying CV cover sheet to Please ensure you detail the names of three referees and quote the job reference number above. A cover letter is optional.

For any informal enquiries about this post, please contact Dr Esther Baena, email:

Additional Information:
On the 26th April 2017 The Paterson Building, which housed most of the Cancer Research UK (CRUK) Manchester Institute, caught fire resulting in significant damage. We shall be rebuilding our world-class research facilities and we would like to make you aware that in the meantime, the primary place of work for this position will be at the internationally-renowned life sciences campus at Alderley Park, which has excellent facilities to carry out research. We anticipate that this will be for a few years, after which we will return to our original site in Withington, Manchester, next to The Christie NHS Foundation Trust (Wilmslow Road, M20 4BX).


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Created Date: 11 February 2019