Publications

Gozdecka M, Lyons S, Kondo S, Taylor J, Li Y, Walczynski J, Thiel G, Breitwieser W, Jones N. JNK Suppresses Tumor Formation via a Gene-Expression Program Mediated by ATF2. Cell Reports. 9(4):1361-74. (2014) 

Walczynski J, Lyons S, Jones N, Breitwieser W. Sensitisation of c-MYC-induced B-lymphoma cells to apoptosis by ATF2. Oncogene. 33(8):1027-36. (2014)

Gozdecka M, Breitwieser W. The roles of ATF2 (activating transcription factor 2) in tumorigenesis. Biochem Soc Trans. 40(1):230-4. (2012)

Di Y, Holmes EJ, Butt A, Dawson K, Mironov A, Kotiadis VN, Gourlay CW, Jones N, Wilkinson CR. H2O2 stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4. EMBO J.  31(3):563-75. (2012)

Ackermann J, Ashton G, Lyons S, James D, Hornung JP, Jones N, Breitwieser W. Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development.  PLoS One. 6(4):e19090. (2011)

Shah M, Bhoumik A, Goel V, Dewing A, Breitwieser W, Kluger H, Krajewski S, Krajewska M, Dehart J, Lau E, Kallenberg DM, Jeong H, Eroshkin A, Bennett DC, Chin L, Bosenberg M, Jones N, Ronai ZA. A role for ATF2 in regulating MITF and melanoma development. PLoS Genet. 6(12):e1001258. (2010)

Li S, Ezhevsky S, Dewing A, Cato MH, Scortegagna M, Bhoumik A, Breitwieser W, Braddock D, Eroshkin A, Qi J, Chen M, Kim JY, Jones S, Jones N, Rickert R, Ronai ZA. Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice. Genes Cancer. 1(4):316-330. (2010)

Li S, Ezhevsky S, Dewing A, Cato MH, Scortegagna M, Bhoumik A, Breitwieser W, Braddock D, Eroshkin A, Qi J, Chen M, Kim JY, Jones S, Jones N, Rickert R, Ronai ZA. Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice. Genes Cancer. 1(4):316-330. (2010)

Nemoto N, Udagawa T, Ohira T, Jiang L, Hirota K, Wilkinson CR, Bähler J, Jones N, Ohta K, Wek RC, Asano K. The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation. J Mol Biol. 404(2):183-201. (2010)

Lawrence CL, Jones N, Wilkinson CR. Stress-induced phosphorylation of S. pombe Atf1 abrogates its interaction with F box protein Fbh1. Curr Biol. 19(22):1907-11. (2009)

Ors A, Grimaldi M, Kimata Y, Wilkinson CR, Jones N, Yamano H. The transcription factor Atf1 binds and activates the APC/C ubiquitin ligase in fission yeast. J Biol Chem. 284(36):23989-94. (2009)

Udagawa T, Nemoto N, Wilkinson CR, Narashimhan J, Jiang L, Watt S, Zook A, Jones N, Wek RC, Bähler J, Asano K. Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 map kinase-dependent stress response in fission yeast. J Biol Chem. 283(32):22063-75. (2008)

Bhoumik A, Fichtman B, Derossi C, Breitwieser W, Kluger HM, Davis S, Subtil A, Meltzer P, Krajewski S, Jones N, Ronai Z. Suppressor role of activating transcription factor 2 (ATF2) in skin cancer. Proc Natl Acad Sci U S A. 105(5):1674-9. (2008)

Chen D, Wilkinson CR, Watt S, Penkett CJ, Toone WM, Jones N, Bähler J. Multiple pathways differentially regulate global oxidative stress responses in fission yeast.  Mol Biol Cell.19(1):308-17. (2008)

Dawson K, Toone WM, Jones N, Wilkinson CR. Loss of regulators of vacuolar ATPase function and ceramide synthesis results in multidrug sensitivity in Schizosaccharomyces pombe. Eukaryot Cell. Jun;7(6):926-37. (2008)

Reiter W, Watt S, Dawson K, Lawrence CL, Bähler J, Jones N, Wilkinson CR. Fission yeast MAP kinase Sty1 is recruited to stress-induced genes. J Biol Chem. 283(15):9945-56. (2008)

Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N. Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 21(16):2069-82. (2007)

Bruhat, A., Cherasse, Y., Maurin, A.C., Breitwieser, W., Parry, L., Deval, C., Jones, N., Jousse, C. and Fafournoux, P. ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation. Nucleic Acids Research. 35:1312-1321. (2007)

Lawrence, C.L., Maekawa, H., Worthington, J.L., Reiter, W., Wilkinson, C.R. and Jones, N. Regulation of Schizosaccharomyces pombe Atf1 protein levels by Sty1-mediated phosphorylation and heterodimerization with Pcr1. J Biol Chem. 282: 5160-5170. (2007)

Sinclair, J., Weeks, M., Butt, A., Worthington, J.L., Akpan, A., Jones, N., Waterfield, M., Allanand, D. and Timms, J.F.  Proteomic response of Schizosaccharomyces pombe to static and oscillating extremely low-frequency electromagnetic fields. Proteomics6: 4755-4764. (2006)

Weeks, M.E., Sinclair, J., Butt, A., Chung, Y.L., Worthington, J.L., Wilkinson, C.R., Griffiths, J., Jones, N., Waterfield, M.D. and Timms, J.F. A parallel proteomic and metabolomic analysis of the hydrogen peroxide- and Sty1p-dependent stress response in Schizosaccharomyces pombe. Proteomics. 6:2772-2796. (2006)

Thornton G, Wilkinson CR, Toone WM, Jones N. A novel pathway determining multidrug sensitivity in Schizosaccharomyces pombe. Genes Cells. 10:941-951. (2005)

Bhoumik A, Takahashi S, Breitwieser W, Shiloh Y, Jones N, Ronai Z. ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. 
Mol Cell. 18:577-587. (2005)

Maehara K, Yamakoshi K, Ohtani N, Kubo Y, Takahashi A, Arase S, Jones N, Hara E.  Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53. J Cell Biol. 14:553-560. (2005)

Harrison C, Katayama S, Dhut S, Chen D, Jones N, Bahler J, Toda T. SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast. EMBO J. 24:599-610. (2005)

Verschuren EW, Jones N, Evan GI. The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin. J Gen Virol. 85:1347-61. Review. (2004)

Wilkinson CR. Ubiquitin-like proteins: meet the family. Semin Cell Dev Biol. 15:199-200. (2004)

Vivancos AP, Castillo EA, Jones N, Ayte J, Hidalgo E.  Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration. Mol Microbiol. 52:1427-1435. (2004)

Bhoumik A, Jones N, Ronai Z. Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity. Proc Natl Acad Sci U S A. 101:4222-4227. (2004)

Wilkinson CR, Dittmar GA, Ohi MD, Uetz P, Jones N, Finley D.  Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. Curr Biol. 14:2283-2288. (2004)

Verschuren EW, Hodgson JG, Gray JW, Kogan S, Jones N, Evan GI.  The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis. Cancer Res. 64:581-589. (2004)

Castillo EA, Vivancos AP, Jones N, Ayte J, Hidalgo E. Schizosaccharomyces pombe cells lacking the Ran-binding protein Hba1 show a multidrug resistance phenotype due to constitutive nuclear accumulation of Pap1. J Biol Chem. 278:40565-40572. (2003)

Chen D, Toone WM, Mata J, Lyne R, Burns G, Kivinen K, Brazma A, Jones N, Bahler J. Global transcriptional responses of fission yeast to environmental stress. Mol Biol Cell. 14:214-229. (2003)

Greenall A, Hadcroft AP, Malakasi P, Jones N, Morgan BA, Hoffman CS, Whitehall SK.  Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress. Mol Biol Cell. 13 , 2977-2989. (2002)

Verschuren EW, Klefstrom J, Evan GI, Jones NJ. The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo. Cancer Cell. 2:229-241. (2002)

Veal, EA, Toone, WM, Jones N, Morgan BA. Distinct roles for glutathione S-transferase in the oxidative stress response in Schizosaccharomyces pombe. J Biol Chem. 277:35523-35531. (2002)

Smith DA, Toone WM, Murchie , DC , Bahler J, Jones N, Morgan BA, Quinn J. The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast J Biol Chem. 277:33411-33421. (2002)

Quinn, J, Findlay VJ, Dawson K, Millar JB, Jones N, Morgan BA, Toone WM. Distinct Regulatory Proteins Control the Graded Transcriptional Response to Increasing H(2)O(2) Levels in Fission Yeast Schizosaccharomyces pombe. Mol Biol Cell. 13:805-16. (2002)

Castillo EA, Ayte J, Chiva C, Moldon A, Carrascal M, Abian J, Jones N, Hidalgo E. Diethylmaleate activates the transcription factor Pap1 by covalent modification of critical cysteine residues. Mol Microbiol. 45:243-254. (2002)

Wilkinson CR. New tricks for ubiquitin and friends. Trends Cell Biol. 12:545-546. (2002)

Pereira PS, Jones NC. The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating. Genes Cells. 6:789-802. (2001)

Laman H, Peters G, Jones N. Cyclin-mediated export of human Orc1. Exp Cell Res. 271:230-237. (2001)

Laman H, Coverley D, Krude T, Laskey R, Jones N. Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication. Mol Cell Biol. 21:624-635. (2001)

Hagan IM, Jones N, Carr AM. New insights into development from mitosis of a unicellular yeast. Dev Cell. 1:158-160. (2001)