Haematopoiesis
Haematopoiesis
GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1
In this study, the authors investigated the molecular mechanisms controlling the generation of HSCs during the intra-embryonic wave of haematopoiesis in the AGM and demonstrate a prominent role for the transcriptional repressors GFI1 and GFI1B in this process.
The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency
The epigenetic factors KAT6A and KMT2A interact in normal hematopoiesis to regulate progenitors’ self-renewal. Authors evaluated the potential of different KAT6A therapeutic targeting strategies to alter the growth of KAT6A and KMT2A rearranged AMLs.
Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE
Here, the authors construct a comprehensive atlas of the endothelial-to-haematopoietic transition (EHT) continuum, as well as the subaortic niche cells in mouse embryonic aorta using a set of haemogenic endothelium (HE) reporter models.