Overview
Our annual Scientific Reports detail the activities of each research group, describing their publications and research projects for the year. It also contains information about technical and operational activities and our funding streams.
The latest Scientific Report highlighted a significant period for our Institute as we made the long-anticipated return to the Paterson Building, our brand-new research facility on the Christie NHS Foundation Trust site. Here you can find out how our staff continued to excel in all aspects of Institute life and reconnected with the wider scientific community within the Manchester Cancer Research Centre.
Our annual Scientific Reports detail the activities of each research group, describing their publications and research projects for the year. It also contains information about technical and operational activities and our funding streams.
The latest Scientific Report highlighted a significant period for our Institute as we made the long-anticipated return to the Paterson Building, our brand-new research facility on the Christie NHS Foundation Trust site. Here you can find out how our staff continued to excel in all aspects of Institute life and reconnected with the wider scientific community within the Manchester Cancer Research Centre.
Scientific Publications
https://doi.org/10.1038/s44161-025-00740-z
Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes
11 November 2025
Institute Authors (6)
Robert Sellers, John Weightman, Wolfgang Breitwieser, Natalia Moncaut, Michael Lie-a-ling, Georges Lacaud
Labs & Facilities
Computational Biology Support, Molecular Biology, Genome Editing and Mouse Models
Research Group
Stem Cell Biology
11 November 2025
https://doi.org/10.1136/jitc-2025-012527
Systemic immunosuppression from ultraviolet radiation exposure inhibits cancer immunotherapy
31 October 2025
Institute Authors (4)
Isabella Mataloni, Antonia Banyard, Garry Ashton, Amaya Virós
Labs & Facilities
Mass and Flow Cytometry, Histology
Research Group
Skin Cancer & Ageing
31 October 2025
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-24-1224/766638/Glucocorticoids-Unleash-Immune-dependent-Melanoma
Glucocorticoids Unleash Immune-dependent Melanoma Control through Inhibition of the GARP/TGF β Axis
15 October 2025
Institute Authors (12)
Charles Earnshaw, Poppy Dunn, Shih-Chieh Chiang, Maria Koufaki, Massimo Russo, Kimberley Hockenhull, Erin Richardson, Anna Pidoux, Alex Baker, Richard Reeves, Robert Sellers, Sudhakar Sahoo
Labs & Facilities
Computational Biology Support, Visualisation, Irradiation and Analysis
Research Group
Cancer Inflammation and Immunity
15 October 2025
/wp-content/uploads/2025/09/Annual_Report_2024.pdf
2024 Annual Report
23 September 2025
23 September 2025
https://doi.org/10.1182/blood.2024028033
An in vivo barcoded CRISPR-Cas9 screen identifies Ncoa4-mediated ferritinophagy as a dependence in Tet2-deficient hematopoiesis
4 September 2025
Institute Authors (1)
Justin Loke
Research Group
Myeloid Cancer Biology
4 September 2025
https://doi.org/10.1038/s41467-024-49692-1
Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma
15 July 2025
Institute Authors (1)
Samra Turajlić
Research Group
Cancer Dynamics
15 July 2025