2023 Newsletter

/wp-content/uploads/2024/11/CRUK-Manchester-Newsletter-Autumn-2023.pdf 27th November 2023

Overview

As an Institute we pride ourselves on being as much a community as a workplace. We are proud to share our successes, both inside and outside of the lab with our supporters, friends, and our wide network of collaborators.

Our newsletters contain details of our recent publications, fundraising efforts, new starters, events and more, and gives an insight into the working life of our staff and students.

The latest edition features our move to the new Paterson Building, welcomes new group leader Evangelos Giampazolias, as well as quinquennial review success for Deputy Director Claus Jorgensen plus much more.

Scientific Publications

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https://doi.org/10.1016/j.ccell.2025.04.001

Stromal lipid species dictate melanoma metastasis and tropism

24 April 2025

Institute Authors (5)

Amaya Viros, Duncan Smith, Garry Ashton, Alex Baker, Tim Somervaille

Labs & Facilities

Biological Mass Spectrometry, Histology, Visualisation, Irradiation and Analysis

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Research Group

Skin Cancer & Ageing

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https://doi.org/10.1038/s41467-025-58343-y

A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma

4 April 2025

Institute Authors (4)

Carlos Lopez-Garcia, Robert Sellers, Sudhakar Sahoo, Caroline Dive

Labs & Facilities

Computational Biology Support

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Research Group

Translational Lung Cancer Biology

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https://doi.org/10.1186/s12943-024-02157-x

The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer

12 November 2024

Institute Authors (1)

Amaya Viros

Labs & Facilities

Genome Editing and Mouse Models

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Research Group

Skin Cancer & Ageing

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https://doi.org/10.1186/s13045-024-01610-0

The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency

8 October 2024

Institute Authors (6)

Georges Lacaud, Mathew Sheridan, Michael Lie-a-ling, Liam Clayfield, Jessica Whittle, Jingru Xu

Research Group

Stem Cell Biology

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/wp-content/uploads/2024/11/Annual-Report-2023.pdf

2023 Annual Report

13 September 2024

https://doi.org/10.1126/science.adh7954

Vitamin D regulates microbiome-dependent cancer immunity

25 April 2024

Institute Authors (3)

Evangelos Giampazolias, Maria Koufaki, Santiago Zelenay

Research Group

Cancer Immunosurveillance

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